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First-line treatment in lymphomatoid papulosis: a retrospective multicentre study

Authors :
Jesús Bastida
Teresa Estrach
J.M. Sanchez Schmidt
F. Valentí-Medina
Rosa M. Martí
Pedro de Paco Sánchez
F. Gallardo
Buenaventura Hernández-Machín
L. Blanch Rius
R. Izu
Ricardo Fernández-de-Misa
S. Pérez Gala
A. Pérez Gil
Cristina Muniesa
Yeray Peñate
Ariadna Ortiz-Brugués
M P García Muret
Ignasi Pau-Charles
Javier Cañueto
Octavio Servitje
M. Morillo
Pablo L. Ortiz-Romero
Ingrid Lopez-Lerma
Ramon M. Pujol
Concepción Román
M. Blanes
Lidia Maroñas-Jiménez
Universitat de Barcelona
Source :
Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, CLINICAL AND EXPERIMENTAL DERMATOLOGY, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante, Consejo Superior de Investigaciones Científicas (CSIC), r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Publication Year :
2017

Abstract

BACKGROUND: Data regarding response to treatment in lymphomatoid papulosis (LyP) are scarce. AIM: To assess the daily clinical practice approach to LyP and the response to first-line treatments. METHODS: This was a retrospective study enrolling 252 patients with LyP. RESULTS: Topical steroids, methotrexate and phototherapy were the most common first-line treatments, prescribed for 35%, 20% and 14% of the patients, respectively. Complete response (CR) was achieved in 48% of treated patients. Eczematous lesions significantly increased relative risk (RR) of not achieving CR (RR = 1.76; 95% CI 1.16-2.11). Overall median time to CR was 10 months (95% CI 6-13 months), and 78% of complete responders showed cutaneous relapse; both results were similar for all treatment groups (P > 0.05). Overall estimated median disease-free survival (DFS) was 11 months (95% CI 9-13 months) but DFS for patients treated with phototherapy was 23 months (95% CI 10-36 months; P

Details

Language :
English
ISSN :
03076938
Database :
OpenAIRE
Journal :
Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, CLINICAL AND EXPERIMENTAL DERMATOLOGY, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante, Consejo Superior de Investigaciones Científicas (CSIC), r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Accession number :
edsair.doi.dedup.....a9d0f440cafafc20f6f5306e69ad25ad