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First-line treatment in lymphomatoid papulosis: a retrospective multicentre study
- Source :
- Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, CLINICAL AND EXPERIMENTAL DERMATOLOGY, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante, Consejo Superior de Investigaciones Científicas (CSIC), r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Publication Year :
- 2017
-
Abstract
- BACKGROUND: Data regarding response to treatment in lymphomatoid papulosis (LyP) are scarce. AIM: To assess the daily clinical practice approach to LyP and the response to first-line treatments. METHODS: This was a retrospective study enrolling 252 patients with LyP. RESULTS: Topical steroids, methotrexate and phototherapy were the most common first-line treatments, prescribed for 35%, 20% and 14% of the patients, respectively. Complete response (CR) was achieved in 48% of treated patients. Eczematous lesions significantly increased relative risk (RR) of not achieving CR (RR = 1.76; 95% CI 1.16-2.11). Overall median time to CR was 10 months (95% CI 6-13 months), and 78% of complete responders showed cutaneous relapse; both results were similar for all treatment groups (P > 0.05). Overall estimated median disease-free survival (DFS) was 11 months (95% CI 9-13 months) but DFS for patients treated with phototherapy was 23 months (95% CI 10-36 months; P
- Subjects :
- Male
Limfomes
Skin Neoplasms
medicine.medical_treatment
Administration, Topical
Gastroenterology
Neoplasms, Multiple Primary
030207 dermatology & venereal diseases
0302 clinical medicine
Epidemiology
Young adult
Lymphomatoid papulosis
Child
Aged, 80 and over
Fototeràpia
Middle Aged
Skin diseases
030220 oncology & carcinogenesis
Child, Preschool
Lymphomas
Female
Steroids
Topical steroid
medicine.drug
Adult
medicine.medical_specialty
Antimetabolites, Antineoplastic
Adolescent
Receptors, Antigen, T-Cell
Dermatology
Disease-Free Survival
03 medical and health sciences
Young Adult
Mycosis Fungoides
Lymphomatoid Papulosis
Internal medicine
medicine
Humans
Aged
Retrospective Studies
Mycosis fungoides
business.industry
Infant
Retrospective cohort study
Phototherapy
medicine.disease
Methotrexate
Malalties de la pell
Relative risk
business
Subjects
Details
- Language :
- English
- ISSN :
- 03076938
- Database :
- OpenAIRE
- Journal :
- Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, CLINICAL AND EXPERIMENTAL DERMATOLOGY, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante, Consejo Superior de Investigaciones Científicas (CSIC), r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
- Accession number :
- edsair.doi.dedup.....a9d0f440cafafc20f6f5306e69ad25ad