Back to Search
Start Over
NKp46 regulates allergic responses
- Source :
- European Journal of Immunology
- Publication Year :
- 2013
- Publisher :
- BlackWell Publishing Ltd, 2013.
-
Abstract
- Natural killer (NK) cells are cytotoxic cells that are able to rapidly kill viruses, tumor cells, parasites, bacteria, and even cells considered “self”. The activity of NK cells is controlled by a fine balance of inhibitory and activating signals mediated by a complex set of different receptors. However, the function of NK cells is not restricted only to the killing of target cells, NK cells also possess other properties such as the secretion of proangiogenic factors during pregnancy. Here, we demonstrate another unique NK-cell activity, namely the regulation of T-cell mediated allergic responses, which is dependent on the NK-cell specific receptor NKp46 (Ncr1 in mice). Using mice in which the Ncr1 gene has been replaced with a green fluorescent protein, we demonstrate reduced delayed-type hypersensitivity and airway hypersensitivity. Interestingly, we show that this reduction in airway hypersensitivity is due to differences in the stimulation of T cells resulting in an altered cytokine profile.
- Subjects :
- Cytotoxicity, Immunologic
Allergy
Ovalbumin
T-Lymphocytes
Immunology
Green Fluorescent Proteins
NK cells
Biology
Lymphocyte Activation
CD49b
03 medical and health sciences
Interleukin 21
Interferon-gamma
Mice
0302 clinical medicine
medicine
Respiratory Hypersensitivity
Immunology and Allergy
Cytotoxic T cell
Animals
Antigens, Ly
Interferon gamma
Hypersensitivity, Delayed
IL-2 receptor
030304 developmental biology
Inflammation
0303 health sciences
Lymphokine-activated killer cell
Natural Cytotoxicity Triggering Receptor 1
Janus kinase 3
Dendritic Cells
Ncr1
Innate Immunity
3. Good health
Killer Cells, Natural
Mice, Inbred C57BL
NKp46
Interleukin 12
030215 immunology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 15214141 and 00142980
- Volume :
- 43
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi.dedup.....a9cdb68701ac0814a920176018a1a578