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Pediatric Glioma Outcomes: Predictors of Early Mortality
- Source :
- World neurosurgery. 139
- Publication Year :
- 2020
-
Abstract
- Objective To assess the early mortality in pediatric glioma and identify predictors of early mortality, which may provide insight into the therapeutic strategies for children with a high risk of early mortality. Methods We used SEER∗Stat 8.3.5 software to extract data of pediatric glioma from the Surveillance, Epidemiology, and End Results database. Logistical regression to identify the independent factors in predicting early mortality. Results A total of 3035 male and 2741 female patients were enrolled in the present study. The death rates within 1 month and 3 months after diagnosis were 1.32% and 2.44%, respectively. Early mortality decreased significantly during the past 40 years. Our results showed that glioblastoma, anaplastic glioma, and oligodendroglioma were risk factors of early mortality for children diagnosed with glioma, whereas advanced age, gross total resection, radiation, and chemotherapy were associated with decreased early mortality. Conclusions We found a decrease in early mortality during the past 40 years. The death rates within 1 month and 3 months after diagnosis were 1.32% and 2.44%, respectively. Age at diagnosis, histologic subtype, the extent of resection, chemotherapy, and radiation were associated with early mortality in pediatric glioma.
- Subjects :
- End results
Male
Pediatrics
medicine.medical_specialty
Adolescent
Databases, Factual
medicine.medical_treatment
Logistic regression
Neurosurgical Procedures
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Glioma
Epidemiology
Pediatric glioma
medicine
Humans
Child
Chemotherapy
business.industry
Brain Neoplasms
Mortality rate
Age Factors
Infant, Newborn
Infant
Margins of Excision
Chemoradiotherapy
medicine.disease
Prognosis
030220 oncology & carcinogenesis
Child, Preschool
Surgery
Female
Neurology (clinical)
Oligodendroglioma
business
030217 neurology & neurosurgery
SEER Program
Subjects
Details
- ISSN :
- 18788769
- Volume :
- 139
- Database :
- OpenAIRE
- Journal :
- World neurosurgery
- Accession number :
- edsair.doi.dedup.....a9bf88a0be1867cb98eb18a0720c27df