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Comparative Analysis of Ebola Virus Glycoprotein Interactions With Human and Bat Cells
- Source :
- Journal of Infectious Diseases; Vol 204, The Journal of Infectious Diseases
- Publication Year :
- 2011
- Publisher :
- OXFORD UNIV PRESS INC, 2011.
-
Abstract
- Infection with Ebola virus (EBOV) causes hemorrhagic fever in humans with high case-fatality rates. The EBOV-glycoprotein (EBOV-GP) facilitates viral entry and promotes viral release from human cells. African fruit bats are believed not to develop disease upon EBOV infection and have been proposed as a natural reservoir of EBOV. We compared EBOV-GP interactions with human cells and cells from African fruit bats. We found that susceptibility to EBOV-GP-dependent infection was not limited to bat cells from potential reservoir species, and we observed that GP displayed similar biological properties in human and bat cells. The only exception was GP localization, which was to a greater extent intracellular in bat cells as compared to human cells. Collectively, our results suggest that GP interactions with fruit bat and human cells are similar and do not limit EBOV tropism for certain bat species.
- Subjects :
- Gene Expression Regulation, Viral
Disease reservoir
Biology
Virus Replication
medicine.disease_cause
Viral Proteins
03 medical and health sciences
Species Specificity
Viral entry
Chiroptera
Cricetinae
medicine
Viral Biology
Animals
Humans
Immunology and Allergy
Natural reservoir
Cells, Cultured
Tropism
Disease Reservoirs
Glycoproteins
030304 developmental biology
chemistry.chemical_classification
Ebolavirus
0303 health sciences
Ebola virus
030306 microbiology
Virology
3. Good health
Infectious Diseases
chemistry
Viral replication
Glycoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 15376613
- Volume :
- 204
- Issue :
- suppl 3
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....a9be52e1faa77b136933c9191bd71ab5
- Full Text :
- https://doi.org/10.1093/infdis/jir306