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Optimization of preparation conditions and in vitro sustained-release evaluation of a novel nanoemulsion encapsulating unsaturated guluronate oligosaccharide
- Source :
- Carbohydrate Polymers. 264:118047
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Unsaturated guluronate oligosaccharide (GOS) was prepared from alginate-derived homopolymeric blocks of guluronic acid by alginate lyase-mediated depolymerization. In this study, a GOS-based water-in-oil-in-water (W1/O/W2) nanoemulsion was prepared, and different influencing factors were investigated. First, linseed oil was selected as the optimal carrier oil. Then, other optimal conditions of the GOS nanoemulsion were determined based on response surface methodology (RSM). Under the optimal conditions, the obtained GOS nanoemulsion showed a spherical structure with an average particle size of 273.93 ± 8.91 nm, and its centrifugal stability was 91.37 ± 0.45 %. Moreover, the GOS nanoemulsion could achieve the aim of sustained release in vitro and be stably stored at 4°C for at least 5 days. This work prepared a novel GOS-based W1/O/W2 nanoemulsion that may effectively address the storage difficulties of unsaturated GOS and provides a valuable contribution to the application of GOS in the food and medicine fields.
- Subjects :
- Linseed Oil
food.ingredient
Polymers and Plastics
Alginates
Drug Compounding
Oligosaccharides
02 engineering and technology
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
food
Drug Stability
Linseed oil
Guluronic acid
Materials Chemistry
Humans
Response surface methodology
Particle Size
Polysaccharide-Lyases
chemistry.chemical_classification
Drug Carriers
Chromatography
Chemistry
Depolymerization
Hexuronic Acids
Organic Chemistry
Oligosaccharide
021001 nanoscience & nanotechnology
In vitro
Nanostructures
0104 chemical sciences
Delayed-Action Preparations
Emulsions
Particle size
0210 nano-technology
Carrier oil
Oxidation-Reduction
Subjects
Details
- ISSN :
- 01448617
- Volume :
- 264
- Database :
- OpenAIRE
- Journal :
- Carbohydrate Polymers
- Accession number :
- edsair.doi.dedup.....a9b4abf61b84bcf3d0d8917f71afb72e
- Full Text :
- https://doi.org/10.1016/j.carbpol.2021.118047