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Optimization of preparation conditions and in vitro sustained-release evaluation of a novel nanoemulsion encapsulating unsaturated guluronate oligosaccharide

Authors :
Weishan Fang
Zhangli Hu
Decheng Bi
Xu Xu
Yan Wu
Li Meiting
Jiang Yi
Hong Xu
Lijun Yao
Source :
Carbohydrate Polymers. 264:118047
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Unsaturated guluronate oligosaccharide (GOS) was prepared from alginate-derived homopolymeric blocks of guluronic acid by alginate lyase-mediated depolymerization. In this study, a GOS-based water-in-oil-in-water (W1/O/W2) nanoemulsion was prepared, and different influencing factors were investigated. First, linseed oil was selected as the optimal carrier oil. Then, other optimal conditions of the GOS nanoemulsion were determined based on response surface methodology (RSM). Under the optimal conditions, the obtained GOS nanoemulsion showed a spherical structure with an average particle size of 273.93 ± 8.91 nm, and its centrifugal stability was 91.37 ± 0.45 %. Moreover, the GOS nanoemulsion could achieve the aim of sustained release in vitro and be stably stored at 4°C for at least 5 days. This work prepared a novel GOS-based W1/O/W2 nanoemulsion that may effectively address the storage difficulties of unsaturated GOS and provides a valuable contribution to the application of GOS in the food and medicine fields.

Details

ISSN :
01448617
Volume :
264
Database :
OpenAIRE
Journal :
Carbohydrate Polymers
Accession number :
edsair.doi.dedup.....a9b4abf61b84bcf3d0d8917f71afb72e
Full Text :
https://doi.org/10.1016/j.carbpol.2021.118047