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Associations of Abdominal Skeletal Muscle Mass, Fat Mass, and Mortality among Men and Women with Stage I–III Colorectal Cancer
- Source :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 29(5), 956-965, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 29 (2020) 5, Cancer Epidemiology Biomarkers & Prevention, 29(5), 956-965. American Association for Cancer Research Inc., Cancer Epidemiology, Biomarkers & Prevention, 29, 956-965, Cancer Epidemiology, Biomarkers & Prevention, 29, 5, pp. 956-965
- Publication Year :
- 2020
- Publisher :
- American Association for Cancer Research (AACR), 2020.
-
Abstract
- Background: The associations of abdominal skeletal muscle mass index (SMI), visceral and subcutaneous adipose tissue (VAT and SAT, respectively), and mortality among patients with stage I–III colorectal cancer may differ for men and women, but only few studies stratified their data into men and women. We investigated associations of abdominal SMI, VAT, and SAT with overall mortality among men and among women with stage I–III colorectal cancer. Methods: SMI, VAT, and SAT were assessed from abdominal CT images for 1,998 patients with stage I–III colorectal cancer diagnosed between 2006 and 2015. Restricted cubic splines (RCS) were used to investigate associations of SMI, VAT, and SAT with overall mortality. Results: Average age of the participants was 67.9 ± 10.6 years and 58% were men. During a median follow-up of 4.3 years, 546 (27%) patients died. Among men, the association of SMI and mortality was statistically significant in a nonlinear way in the RCS analyses, with lower SMI levels associated with higher mortality. SMI was not associated with mortality among women. SAT was associated with mortality in a nonlinear way for men and for women, with lower SAT levels being associated with higher mortality. VAT was not significantly associated with mortality in men or women. Conclusion: Associations of abdominal skeletal muscle mass with mortality among patients with colorectal cancer were not the same for men and for women. Impact: This study stresses the importance for more attention on sex-related differences in body composition and cancer outcomes.
- Subjects :
- Male
0301 basic medicine
Nutrition and Disease
Epidemiology
Colorectal cancer
Abdominal ct
Body Mass Index
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
Risk Factors
Voeding en Ziekte
Prospective Studies
Stage (cooking)
Abdominal Muscles
Human Nutrition & Health
OUTCOMES
Humane Voeding & Gezondheid
Middle Aged
CHEMOTHERAPY
Oncology
030220 oncology & carcinogenesis
Body Composition
SURVIVAL
Female
SEX
HEALTH
SUBCUTANEOUS ADIPOSE-TISSUE
Colorectal Neoplasms
medicine.medical_specialty
BODY-COMPOSITION
RESECTION
Abdominal Fat
Risk Assessment
Fat mass
03 medical and health sciences
Sex Factors
All institutes and research themes of the Radboud University Medical Center
Internal medicine
medicine
Humans
Life Science
SARCOPENIC OBESITY
Sarcopenic obesity
Aged
Neoplasm Staging
VLAG
business.industry
Cancer
medicine.disease
Skeletal muscle mass
030104 developmental biology
PROGNOSTIC-FACTOR
Subcutaneous adipose tissue
Tomography, X-Ray Computed
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15387755 and 10559965
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiology, Biomarkers & Prevention
- Accession number :
- edsair.doi.dedup.....a99916175b8c6a3daf88c74a7a2e70e9