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Adiponectin and pro‐inflammatory cytokines are modulated in Vietnamese patients with type 2 diabetes mellitus
- Source :
- Journal of Diabetes Investigation
- Publication Year :
- 2016
- Publisher :
- John Wiley and Sons Inc., 2016.
-
Abstract
- Aims/Introduction Adipose tissue‐derived hormones are associated with metabolic disorders including type 2 diabetes mellitus. The present study investigated the levels of adiponectin and pro‐inflammatory cytokines including tumor necrosis factor‐α (TNF‐α), interleukin‐1 beta (IL‐1β) and IL‐10 in Vietnamese patients with type 2 diabetes mellitus, and their correlations with clinical parameters of overweight and type 2 diabetes mellitus. Materials and Methods Based on body mass index, 73 patients with type 2 diabetes mellitus were categorized either as overweight or non‐overweight. As healthy controls, 57 overweight and non‐overweight individuals without type 2 diabetes mellitus were included. The adiponectin, TNF‐α, IL‐1β and IL‐10 levels were measured in the sera samples in all study participants by enzyme‐linked immunosorbent assay and were correlated with clinical parameters. Results The adiponectin levels were lower in patients with type 2 diabetes mellitus (2.5 ± 1.5 μg/mL) compared with controls (16 ± 18.6 μg/mL; P < 0.0001), and were decreased in overweight individuals compared with those who were not overweight. The TNF‐α and IL‐1β levels were increased, whereas the IL‐10 levels were decreased in patients with type 2 diabetes mellitus and in overweight controls compared with non‐overweight controls (P < 0.0001). The adiponectin levels were correlated with the TNF‐α, IL‐1β, IL‐10 levels, and the clinical parameters of overweight and type 2 diabetes mellitus. The quantitative insulin sensitivity check index and homeostasis model assessment insulin resistance indexes were correlated with the relative ratios of adiponectin/TNF‐α, adiponectin/IL‐1β, adiponectin/IL‐10, TNF‐α/IL‐10 and IL‐1β/IL‐10. Conclusions Adiponectin and pro‐inflammatory cytokines are associated with type 2 diabetes mellitus, and might serve as a prognostic marker and a therapeutic intervention for overweight‐related type 2 diabetes mellitus.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Interleukin-1beta
Adipose tissue
030209 endocrinology & metabolism
Overweight
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
Asian People
Internal medicine
Diabetes mellitus
Type 2 diabetes mellitus
Internal Medicine
medicine
Humans
Aged
Adiponectin
business.industry
Tumor Necrosis Factor-alpha
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
General Medicine
Articles
Middle Aged
medicine.disease
Interleukin-10
030104 developmental biology
Endocrinology
Clinical Science and Care
Diabetes Mellitus, Type 2
Vietnam
Cytokines
Original Article
Female
medicine.symptom
Inflammation Mediators
business
Body mass index
Biomarkers
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 20401124 and 20401116
- Volume :
- 8
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Investigation
- Accession number :
- edsair.doi.dedup.....a9955301210565aa368ea732d0e45d92