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Synthetic and therapeutic applications of ammonia-lyases and aminomutases
- Publication Year :
- 2018
-
Abstract
- Ammonia-lyases and aminomutases are mechanistically and structurally diverse enzymes which catalyze the deamination and/or isomerization of amino acids in nature by cleaving or shifting a C–N bond. Of the many protein families in which these enzyme activities are found, only a subset have been employed in the synthesis of optically pure fine chemicals or in medical applications. This review covers the natural diversity of these enzymes, highlighting particular enzyme classes that are used within industrial and medical biotechnology. These highlights detail the discovery and mechanistic investigations of these commercially relevant enzymes, along with comparisons of their various applications as stand-alone catalysts, components of artificial biosynthetic pathways and biocatalytic or chemoenzymatic cascades, and therapeutic tools for the potential treatment of various pathologies.
- Subjects :
- 0301 basic medicine
Models, Molecular
Ammonia-Lyases
Bacteria
Biocatalysis
Humans
Intramolecular Transferases
Phenylalanine Ammonia-Lyase
Substrate Specificity
Transaminases
Deamination
01 natural sciences
03 medical and health sciences
Models
chemistry.chemical_classification
010405 organic chemistry
Molecular
General Chemistry
0104 chemical sciences
Amino acid
030104 developmental biology
Enzyme
chemistry
Biochemistry
Substrate specificity
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a9940a4e75438f231c815e970f104977