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Limits to the rate of information transmission through the MAPK pathway
- Source :
- Journal of the Royal Society Interface
- Publication Year :
- 2019
- Publisher :
- The Royal Society, 2019.
-
Abstract
- Two important signalling pathways of NF-κB and ERK transmit merely 1 bit of information about the level of extracellular stimulation. It is thus unclear how such systems can coordinate complex cell responses to external cues. We analyse information transmission in the MAPK/ERK pathway that converts both constant and pulsatile EGF stimulation into pulses of ERK activity. Based on an experimentally verified computational model, we demonstrate that, when input consists of sequences of EGF pulses, transmitted information increases nearly linearly with time. Thus, pulse-interval transcoding allows more information to be relayed than the amplitude–amplitude transcoding considered previously for the ERK and NF-κB pathways. Moreover, the information channel capacity C, or simply bitrate, is not limited by the bandwidth B = 1/ τ , where τ ≈ 1 h is the relaxation time. Specifically, when the input is provided in the form of sequences of short binary EGF pulses separated by intervals that are multiples of τ / n (but not shorter than τ ), then for n = 2, C ≈ 1.39 bit h −1 ; and for n = 4, C ≈ 1.86 bit h −1 . The capability to respond to random sequences of EGF pulses enables cells to propagate spontaneous ERK activity waves across tissue.
- Subjects :
- MAPK/ERK pathway
cellular signal transduction
bandwidth
MAP Kinase Signaling System
Biomedical Engineering
Biophysics
Bioengineering
Biochemistry
Models, Biological
Biomaterials
Text mining
Extracellular stimulation
medicine
Animals
Humans
Extracellular Signal-Regulated MAP Kinases
Information transmission
business.industry
Chemistry
Bandwidth (signal processing)
representation problem
Complex cell
Cellular signal transduction
Cell biology
medicine.anatomical_structure
pulsatile stimulation
Life Sciences–Mathematics interface
business
pulse–interval transcoding
Signalling pathways
Biotechnology
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17425662 and 17425689
- Volume :
- 16
- Issue :
- 152
- Database :
- OpenAIRE
- Journal :
- Journal of the Royal Society Interface
- Accession number :
- edsair.doi.dedup.....a987bf3d0a2743a228fc4051a94f7f23