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Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression
- Source :
- Immunogenetics. 54(8)
- Publication Year :
- 2002
-
Abstract
- Genomic DNA from a panel of 41 healthy unrelated Japanese individuals was typed for the presence or absence of 16 KIR genes and pseudogenes. Only eight different KIR genotypes were found. Group A haplotypes outnumbered group B haplotypes in frequency by approximately 3:1, with individuals having two group A haplotypes accounting for 56% of the panel. The frequency of A haplotypes in the Japanese is higher than that observed in other populations. Flow cytometric comparison of KIR expression in 19 panel members showed considerable diversity in NK cell repertoire, which was also seen within the group of individuals having two A haplotypes. This diversity is likely due to allelic polymorphism in expressed genes of the A haplotype. In comparison to other populations, the Japanese appear less heterogeneous in KIR genotype as assessed by gene content.
- Subjects :
- Adult
Male
Genotype
Pseudogene
Immunology
Killer-cell immunoglobulin-like receptor
Biology
Gene Frequency
Japan
Receptors, KIR
Genetic variation
Genetics
Humans
Receptors, Immunologic
Allele frequency
Haplotype
Genetic Variation
Middle Aged
Flow Cytometry
Killer Cells, Natural
KIR3DL2
Haplotypes
Female
Pseudogenes
KIR2DS4
Subjects
Details
- ISSN :
- 00937711
- Volume :
- 54
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Immunogenetics
- Accession number :
- edsair.doi.dedup.....a97c32d108a694233534aee1c3b16d03