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Microalbuminuria in Patients with Obstructive Sleep Apnea–Chronic Obstructive Pulmonary Disease Overlap Syndrome
- Source :
- Annals of the American Thoracic Society. 13:917-925
- Publication Year :
- 2016
- Publisher :
- American Thoracic Society, 2016.
-
Abstract
- Microalbuminuria is said to reflect systemic vascular damage and endothelial dysfunction and is an established indicator of cardiovascular morbidity and mortality. Patients with obstructive sleep apnea (OSA)-chronic obstructive pulmonary disease (COPD) overlap syndrome have worse survival than those with OSA or COPD alone.This study evaluated the association between overlap syndrome and microalbuminuria.Data on patients in whom OSA was suspected and who underwent polysomnography between January 2010 and December 2012 were reviewed. Microalbuminuria was defined as an albumin-creatinine ratio between 20 and 299 mg/g in men and between 30 and 299 mg/g in women.Of 740 consecutive patients, 344 were analyzed. Sixty-four were control participants, 248 had OSA only, 4 had COPD only, and 28 had OSA-COPD overlap syndrome. Prevalence of microalbuminuria significantly increased in the order of control, OSA, and overlap syndrome groups (3.1, 12.9, and 32.1%, respectively; P = 0.0006). After adjusting for age and sex, multivariate logistic regression analysis demonstrated a significant association of overlap syndrome with microalbuminuria compared with OSA (odds ratio, 2.61; 95% confidence interval, 1.02-6.38; P = 0.047), but after adjusting for other confounding factors, the difference in the association did not reach significance (odds ratio, 2.54; 95% confidence interval, 0.93-6.72; P = 0.070). Of 63 patients reevaluated after 3 months of continuous positive airway pressure therapy, the logarithm of the albumin-creatinine ratio in 36 patients with good compliance significantly decreased, but there was no difference in patients with poor compliance.OSA-COPD overlap syndrome was more prevalent than OSA alone in patients with microalbuminuria, but the difference might be mediated by conventional risk factors rather than the addition of COPD itself.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Polysomnography
medicine.medical_treatment
030204 cardiovascular system & hematology
Severity of Illness Index
Pulmonary Disease, Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Japan
Risk Factors
Internal medicine
Severity of illness
Albuminuria
Humans
Medicine
Continuous positive airway pressure
Serum Albumin
Aged
Sleep Apnea, Obstructive
COPD
Continuous Positive Airway Pressure
medicine.diagnostic_test
business.industry
Overlap syndrome
Middle Aged
medicine.disease
respiratory tract diseases
Obstructive sleep apnea
Logistic Models
030228 respiratory system
Multivariate Analysis
Cardiology
Physical therapy
Female
Microalbuminuria
medicine.symptom
business
Subjects
Details
- ISSN :
- 23256621 and 23296933
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Annals of the American Thoracic Society
- Accession number :
- edsair.doi.dedup.....a96fcf082db1fbc1ae56c4e749250fd1