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Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy
- Source :
- Journal of Clinical Neuroscience. 20:1492-1497
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- The effects of the antiepileptic drugs sodium valproate (VPA) and levetiracetam (LEV) on reproductive endocrine function, sexual function, and spermatozoa were explored, together with their possible etiological mechanisms, in Chinese Han men with epilepsy. Following VPA treatment (n = 32), luteinizing hormone and follicle-stimulating hormone levels were significantly lower than in controls (n = 30). The bioactive testosterone/luteinizing hormone ratio and the prolactin level were significantly elevated in the VPA treatment group. There were no significant differences in these hormones between the LEV treatment (n = 20) and control groups. The rates of sperm morphologic abnormality (head, body, and tail) were significantly higher in the VPA treatment group than the control group but did not differ significantly between the LEV treatment and control groups. The sperm motility rate was significantly lower in the VPA treatment group (grade A sperm motility rate
- Subjects :
- Adult
Male
medicine.medical_specialty
Levetiracetam
Adolescent
Young Adult
Sex hormone-binding globulin
Asian People
Erectile Dysfunction
Physiology (medical)
Internal medicine
medicine
Humans
Endocrine system
Testosterone
Infertility, Male
Sperm motility
Epilepsy
biology
business.industry
Valproic Acid
General Medicine
Luteinizing Hormone
Middle Aged
Piracetam
Spermatozoa
Sperm
Endocrinology
Neurology
biology.protein
Anticonvulsants
lipids (amino acids, peptides, and proteins)
Surgery
Neurology (clinical)
Follicle Stimulating Hormone
Sexual function
Luteinizing hormone
business
Hormone
Subjects
Details
- ISSN :
- 09675868
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....a95e1e12381a193b76fa08287bee3d7d