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Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis
- Source :
- Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences, Journal of Research in Medical Sciences, Vol 20, Iss 7, Pp 668-674 (2015)
- Publication Year :
- 2015
- Publisher :
- Medknow Publications & Media Pvt Ltd, 2015.
-
Abstract
- Background: Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. Materials and Methods: One hundred and sixty women were included, divided into two study groups (Group I - endometriosis; Group 2 - healthy women). We evaluated the serum levels of interleukin-1 receptor antagonist (IL-1Ra), IL-2, IL-2R, IL-4, IL-10, IL-13, and IL-15 with the use of Human multiplex cytokine panels. Statistical analyses (normality distribution analysis, independent t-test, Mann-Whitney U-test) were performed using IBM SPSS software (version 22.0) and GraphPad Prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers. Results: The mean serum level of IL-1Ra, IL-4, and IL-10 were significantly higher in women with endometriosis compared to women free of disease from the control group (30.155, 138.459, and 1.489, respectively, compared to 14.109, 84.710, and 0.688, respectively; P < 0.001, P < 0.001, and P = 0.002, respectively.). No significant differences in the mean serum levels of IL-2, IL-13, and IL-15 were observed between the studied groups and IL-2R had a very low detection rate. Conclusion: Endometriosis is associated with elevated levels of anti-inflammatory cytokines, IL-1Ra, IL-4, and IL-10, markers that have a potential role as a prognostic factor for endometriosis.
- Subjects :
- endometriosis
medicine.medical_specialty
medicine.medical_treatment
Endometriosis
lcsh:Medicine
Inflammation
Disease
Gastroenterology
Pathogenesis
Immunity
Internal medicine
medicine
Receiver operating characteristic
business.industry
interleukin
lcsh:R
Interleukin
General Medicine
medicine.disease
immunity
Cytokine
inflammation
Immunology
Cytokines
Original Article
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 17357136 and 17351995
- Volume :
- 20
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences
- Accession number :
- edsair.doi.dedup.....a94cd37cef6859d84dfdfb24817a5041