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Multi‐organism gastrointestinal polymerase chain reaction positivity among pediatric transplant vs non‐transplant populations: A single‐center experience
- Source :
- Pediatr Transplant
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- BACKGROUND: Diarrhea is a common problem in the pediatric post-solid organ transplant and post-hematopoietic stem cell transplant populations. Infectious etiology incidences are poorly defined, and the possibility of multi-organism positivity is often uninvestigated. The aim of this study is to utilize stool multiplex GIP assays to compare the PTP and NTP regarding the incidence and profiles of single-organism and multi-organism infectious diarrhea. METHODS: A single-center retrospective review was conducted, investigating stool multiplex GIP panel results over a more than 3-year period, for pediatric patients. Assays test for 23 viral, bacterial, and protozoal organisms. RESULTS: Positive assays in the PTP and NTP were 70/101 (69.3%) and 962/1716 (56.1%), respectively (P = .009). Thirty-two percent (32/101) of assays within the PTP were multi-organism positive, significantly more than 14.8% (254/1716) in the NTP (P < .00001). There was no significant difference in the incidence of single-organism positives, 37.6% (38/101) in PTP and 41.3% (708/1716) in the NTP. The PTP demonstrated a statistically significantly higher incidence of the following organisms within multi-agent positive GIPs (P < .05 for each): Clostridioides difficile, Cryptosporidium, EPEC, norovirus, and sapovirus. CONCLUSIONS: The pediatric PTP demonstrates higher incidence of positive GIPs, higher rate of multi-organism positivity, and unique infectious organism incidence profiles. These data can provide a framework for understanding organism-specific pathogenicity factors, assessing the clinical impact of enteric co-infection, and understanding the utility of this testing modality in this unique population.
- Subjects :
- Male
030232 urology & nephrology
Cryptosporidiosis
030230 surgery
Single Center
medicine.disease_cause
Pediatrics
Polymerase Chain Reaction
Gastroenterology
Organ transplantation
Enteropathogenic Escherichia coli
Feces
0302 clinical medicine
Child
education.field_of_study
biology
Incidence
Incidence (epidemiology)
Hematopoietic Stem Cell Transplantation
Cryptosporidium
Diarrhea
Treatment Outcome
Child, Preschool
Female
medicine.symptom
medicine.medical_specialty
Adolescent
Population
Article
Sapovirus
03 medical and health sciences
Internal medicine
medicine
Humans
education
Retrospective Studies
Transplantation
Clostridioides difficile
business.industry
Norovirus
Infant, Newborn
Infant
Organ Transplantation
biology.organism_classification
Pediatrics, Perinatology and Child Health
Quality of Life
business
Subjects
Details
- ISSN :
- 13993046 and 13973142
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Pediatric Transplantation
- Accession number :
- edsair.doi.dedup.....a9370d70281e794c6ea2586726862390