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Boosted Regeneration and Reduced Denervated Muscle Atrophy by NeuroHeal in a Pre-clinical Model of Lumbar Root Avulsion with Delayed Reimplantation
- Source :
- Scientific Reports, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- The “gold standard” treatment of patients with spinal root injuries consists of delayed surgical reconnection of nerves. The sooner, the better, but problems such as injury-induced motor neuronal death and muscle atrophy due to long-term denervation mean that normal movement is not restored. Herein we describe a preclinical model of root avulsion with delayed reimplantation of lumbar roots that was used to establish a new adjuvant pharmacological treatment. Chronic treatment (up to 6 months) with NeuroHeal, a new combination drug therapy identified using a systems biology approach, exerted long-lasting neuroprotection, reduced gliosis and matrix proteoglycan content, accelerated nerve regeneration by activating the AKT pathway, promoted the formation of functional neuromuscular junctions, and reduced denervation-induced muscular atrophy. Thus, NeuroHeal is a promising treatment for spinal nerve root injuries and axonal regeneration after trauma.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Nerve root
Acamprosate
lcsh:Medicine
Article
Rats, Sprague-Dawley
Avulsion
03 medical and health sciences
0302 clinical medicine
Atrophy
Lumbar
Ribavirin
medicine
Animals
lcsh:Science
Muscle, Skeletal
Radiculopathy
Denervation
Lumbar Vertebrae
Multidisciplinary
business.industry
Regeneration (biology)
lcsh:R
Recovery of Function
medicine.disease
Muscle Denervation
Muscle atrophy
Nerve Regeneration
Surgery
Disease Models, Animal
Drug Combinations
Muscular Atrophy
Neuroprotective Agents
030104 developmental biology
Gliosis
Replantation
Anesthesia
lcsh:Q
Female
medicine.symptom
Spinal Nerve Roots
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....a933de4ac9b32524b72d027dd29aa2fb