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Oxidative metabolism in the cardiorespiratory system after an acute exposure to nickel-doped nanoparticles in mice
- Source :
- Toxicology. 464:153020
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- There is an increasing concern over the harmful effects that metallic nanoparticles (NP) may produce on human health. Due to their redox properties, nickel (Ni) and Ni-containing NP are particularly relevant. Hence, the aim of this study was to establish the toxicological mechanisms in the cardiorespiratory oxidative metabolism initiated by an acute exposure to Ni-doped-NP. Mice were intranasally instilled with silica NP containing Ni (II) (Ni-NP) (1 mg Ni (II)/kg body weight) or empty NP as control, and 1 h after exposure lung, plasma, and heart samples were obtained to assess the redox metabolism. Results showed that, NP were mainly retained in the lungs triggering a significantly increased tissue O2 consumption rate, leading to Ni-NP-increased reactive oxygen species production by NOX activity, and mitochondrial H2O2 production rate. In addition, an oxidant redox status due to an altered antioxidant system showed by lung GSH/GSSG ratio decreased, and SOD activity increased, resulting in an increased phospholipid oxidation. Activation of circulating polymorphonuclear leukocytes, along with GSH/GSSG ratio decreased, and phospholipid oxidation were found in the Ni-NP-group plasma samples. Consequently, in distant organs such as heart, Ni-NP inhalation alters the tissue redox status. Our results showed that the O2 metabolism analysis is a critical area of study following Ni-NP inhalation. Therefore, this work provides novel data linking the redox metabolisms alterations elicited by exposure to Ni (II) adsorbed to NP and cardiorespiratory toxicity.
- Subjects :
- Male
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Metal Nanoparticles
Toxicology
medicine.disease_cause
Redox
Antioxidants
nickel
Mice
chemistry.chemical_compound
Oxygen Consumption
Internal medicine
medicine
Animals
Lung
reactive oxygen species
chemistry.chemical_classification
Reactive oxygen species
NADPH oxidase
Inhalation
Chemistry
Ambientale
Glutathione
Metabolism
Silicon Dioxide
Mitochondria
Oxidative Stress
Endocrinology
Toxicity
nanoparticles
Female
Oxidation-Reduction
Oxidative stress
Subjects
Details
- ISSN :
- 0300483X
- Volume :
- 464
- Database :
- OpenAIRE
- Journal :
- Toxicology
- Accession number :
- edsair.doi.dedup.....a92def9beda9b7770267e595017ff491