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Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs
- Source :
- Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021), Genome Biology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- PIWI proteins, a subfamily of PAZ/PIWI Domain family RNA-binding proteins, are best known for their function in silencing transposons and germline development by partnering with small noncoding RNAs called PIWI-interacting RNAs (piRNAs). However, recent studies have revealed multifaceted roles of the PIWI-piRNA pathway in regulating the expression of other major classes of RNAs in germ cells. In this review, we summarize how PIWI proteins and piRNAs regulate the expression of many disparate RNAs, describing a highly complex global genomic regulatory relationship at the RNA level through which piRNAs functionally connect all major constituents of the genome in the germline.
- Subjects :
- Transposable element
endocrine system
Subfamily
lcsh:QH426-470
Pseudogene
Piwi-interacting RNA
Review
Biology
Genome
Germline
Animals
Drosophila Proteins
Gene silencing
Gene Silencing
RNA, Messenger
RNA, Small Interfering
Caenorhabditis elegans
lcsh:QH301-705.5
Genetics
urogenital system
Gene Expression Regulation, Developmental
RNA-Binding Proteins
RNA
lcsh:Genetics
Germ Cells
lcsh:Biology (General)
DNA Transposable Elements
Drosophila
RNA, Long Noncoding
Pseudogenes
Subjects
Details
- ISSN :
- 1474760X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Genome Biology
- Accession number :
- edsair.doi.dedup.....a928fb122e1efa0b683eddbea81b0c80