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Probing the Therapeutic Potential of Marine Phyla by SPE Extraction
- Source :
- Marine Drugs, Vol 19, Iss 640, p 640 (2021), Marine Drugs, Volume 19, Issue 11
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The marine environment is potentially a prolific source of small molecules with significant biological activities. In recent years, the development of new chromatographic phases and the progress in cell and molecular techniques have facilitated the search for marine natural products (MNPs) as novel pharmacophores and enhanced the success rate in the selection of new potential drug candidates. However, most of this exploration has so far been driven by anticancer research and has been limited to a reduced number of taxonomic groups. In this article, we report a test study on the screening potential of an in-house library of natural small molecules composed of 285 samples derived from 57 marine organisms that were chosen from among the major eukaryotic phyla so far represented in studies on bioactive MNPs. Both the extracts and SPE fractions of these organisms were simultaneously submitted to three different bioassays—two phenotypic and one enzymatic—for cytotoxic, antidiabetic, and antibacterial activity. On the whole, the screening of the MNP library selected 11 potential hits, but the distribution of the biological results showed that SPE fractionation increased the positive score regardless of the taxonomic group. In many cases, activity could be detected only in the enriched fractions after the elimination of the bulky effect due to salts. On a statistical basis, sponges and molluscs were confirmed to be the most significant source of cytotoxic and antimicrobial products, but other phyla were found to be effective with the other therapeutic targets.
- Subjects :
- Aquatic Organisms
QH301-705.5
small molecule
Pharmaceutical Science
Antineoplastic Agents
Chemical Fractionation
010402 general chemistry
01 natural sciences
Article
active metabolite
Antineoplastic Agent
cytotoxic
antimicrobial and antidiabetic activity
Drug Discovery
drug discovery platform
VDP::Mathematics and natural science: 400::Zoology and botany: 480
Animals
14. Life underwater
Biology (General)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
marine natural product
Animal
010405 organic chemistry
Chemistry
Phylum
Extraction (chemistry)
marine natural products
active metabolites
Antimicrobial
Small molecule
Porifera
0104 chemical sciences
small molecules
Biochemistry
Mollusca
Pharmacophore
pre-fractionation method
Antibacterial activity
VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 19
- Issue :
- 640
- Database :
- OpenAIRE
- Journal :
- Marine Drugs
- Accession number :
- edsair.doi.dedup.....a92756f4a65a40bfc725a2304d268e35