Erythrocyte Repopulation in X-Irradiated Recipients of Nucleated, Peripheral Blood Cells of Normal Mice

Strains of mice are being prcduced that are isogenic with inbred stocks except for the hemoglobin locus. With mice of such strains, experiments were carried out to ascertain whether peripheral blcod of normal mice contains cells capable of repopulating the marrow of irradiated recipients. In 3 of 5 recipients injected intravenously with approximately 100 million nucleated peripheral blood cells after 600 r, increasing numbers of graft-derived erythrocytes were noted within 60 days after treatment, indicating the presence in peripheral blood of cells that are able to give rise to mature erythrocytes. (auth)