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Bacterial siderophores in community and host interactions
- Source :
- Nature Reviews Microbiology, Nat Rev Microbiol
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Iron is an essential trace element for most organisms. A common way for bacteria to acquire this nutrient is through the secretion of siderophores, which are secondary metabolites that scavenge iron from environmental stocks and deliver it to cells via specific receptors. While there has been tremendous interest in understanding the molecular basis of siderophore synthesis, uptake and regulation, questions about the ecological and evolutionary consequences of siderophore secretion have only recently received increasing attention. In this Review, we outline how eco-evolutionary questions can complement the mechanistic perspective and help to obtain a more integrated view of siderophores. In particular, we explain how secreted diffusible siderophores can affect other community members, leading to cooperative, exploitative and competitive interactions between individuals. These social interactions in turn can spur co-evolutionary arms races between strains and species, lead to ecological dependencies between them and potentially contribute to the formation of stable communities. In brief, this Review shows that siderophores are much more than just iron carriers: they are important mediators of interactions between members of microbial assemblies and the eukaryotic hosts they inhabit.
- Subjects :
- 0303 health sciences
Siderophore
Bacteria
General Immunology and Microbiology
030306 microbiology
Host (biology)
Iron
2404 Microbiology
Siderophores
2725 Infectious Diseases
580 Plants (Botany)
Biology
Biological Evolution
Microbiology
Article
UFSP13-7 Evolution in Action: From Genomes to Ecosystems
03 medical and health sciences
Infectious Diseases
Evolutionary biology
2400 General Immunology and Microbiology
Siderophore synthesis
Microbial Interactions
Selection, Genetic
11493 Department of Quantitative Biomedicine
Subjects
Details
- ISSN :
- 17401534 and 17401526
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Microbiology
- Accession number :
- edsair.doi.dedup.....a910bce6028b0cb9e9819e1c4088a81a