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Comprehensive analysis for diagnosis of preoperative non-invasive follicular thyroid neoplasm with papillary-like nuclear features
- Source :
- PLoS ONE, Vol 14, Iss 7, p e0218046 (2019), PLoS ONE
- Publication Year :
- 2019
- Publisher :
- Public Library of Science (PLoS), 2019.
-
Abstract
- ObjectiveThe current paradigm in the treatment of patients with non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a diagnostic lobectomy rather than complete thyroidectomy and postoperative radioiodine treatment. Consequently, preoperative diagnosis of NIFTP is considered to be important.MethodsWe performed the comprehensive analysis for diagnosis of preoperative 20 NIFTPs in comparison with 41 invasive encapsulated follicular papillary thyroid carcinomas (I-EFVPTCs) using the Korean Thyroid Imaging Reporting and Data System (K-TIRADS), Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), and molecular analysis for BRAF and RAS mutations.ResultsK-TIRADS 3 was identified as the most common sonographic diagnosis in both NIFTP and I-EFVPTC. Unlike I-EFVPTC, K-TIRADS 5 was not identified in NIFTP. AUS/FLUS was the most common cytopathological diagnosis and none of the cases were classified as malignant category in both groups, although the difference in distribution was not significant between the groups. BRAF mutation was not found in NIFTP but was present in 9.8% of cases in I-EFVPTC. The frequency of RAS mutation in I-EFVPTCs was twice as high as that of NIFTP. Wild-type BRAF and RAS in NIFTP was significantly higher than I-EFVPTC.ConclusionThe existence of overlapping features between the groups was evident, hence conclusive distinction between radiology, cytology and molecular analysis could not be achieved. Apparently, the diagnosis of NIFTP based on comprehensive analysis was not confirmable but could perceive or at least favor the diagnosis of NIFTP.
- Subjects :
- Male
Physiology
Artificial Gene Amplification and Extension
Carcinoma, Papillary, Follicular
medicine.disease_cause
Polymerase Chain Reaction
Lung and Intrathoracic Tumors
Diagnostic Radiology
0302 clinical medicine
Thymic Tumors
Neoplasms
Cytology
Ultrasound Imaging
Follicular phase
Medicine and Health Sciences
Endocrine Tumors
Ultrasonography
Thyroid
Multidisciplinary
Radiology and Imaging
Middle Aged
Bethesda system for reporting thyroid cytopathology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Medicine
Female
Radiology
Anatomy
Research Article
Adult
Proto-Oncogene Proteins B-raf
medicine.medical_specialty
Adolescent
Imaging Techniques
Science
Endocrine System
030209 endocrinology & metabolism
Research and Analysis Methods
Carcinomas
Preoperative care
Calcification
Thyroid carcinoma
03 medical and health sciences
Diagnostic Medicine
Preoperative Care
Cancer Detection and Diagnosis
medicine
Carcinoma
Humans
Thyroid Neoplasms
Molecular Biology Techniques
Molecular Biology
Thyroid neoplasm
Aged
business.industry
Biology and Life Sciences
Cancers and Neoplasms
Cell Biology
Papillary Thyroid Carcinoma
medicine.disease
Mutation
ras Proteins
Thyroid Carcinomas
Physiological Processes
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....a8fbc41331db576775c78e71f9fecd06