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Triple negative breast cancer: outcome correlation with immunohistochemical detection of basal markers
- Source :
- The American journal of surgical pathology. 34(7)
- Publication Year :
- 2010
-
Abstract
- We earlier evaluated the relationship of 653 triple negative breast cancers (TNBC) with basal immunophenotypic expression by using antibodies to basal cytokeratins (CK5/6, CK14, CK17, 34betaE12), p63, smooth muscle actin (SMA), epidermal growth factor receptor, and CD117, and found that a triple panel of CK14, 34betaE12 and epidermal growth factor receptor determined 84% of our cases to be basal-like. Women with basal-like TNBC tended to be younger (P=0.04), have histologically higher-grade tumors (P=0.047), with positive nodal status (P=0.047), than those whose tumors were nonbasal-like. Using univariate Cox regression analysis, tumor size (P=0.003), histologic grade (P=0.006), and nodal status (P=0.017) were significant factors for disease-free survival (DFS) among TNBC, whereas age (P=0.004), tumor size (P=0.001), histologic grade (P
- Subjects :
- Oncology
Adult
medicine.medical_specialty
Pathology
Lymphovascular invasion
Breast Neoplasms
Kaplan-Meier Estimate
Biology
Disease-Free Survival
Pathology and Forensic Medicine
Cohort Studies
Basal (phylogenetics)
Breast cancer
Internal medicine
medicine
Humans
Triple-negative breast cancer
Mastectomy
Aged
Biologic marker
Aged, 80 and over
Singapore
Keratin-17
CD117
Carcinoma, Ductal, Breast
Cancer
Muscle, Smooth
Middle Aged
medicine.disease
Actins
Proto-Oncogene Proteins c-kit
Carcinoma, Intraductal, Noninfiltrating
Phenotype
biology.protein
Surgery
Female
Breast disease
Lymph Nodes
Anatomy
Biomarkers
Subjects
Details
- ISSN :
- 15320979
- Volume :
- 34
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- The American journal of surgical pathology
- Accession number :
- edsair.doi.dedup.....a8f9e4cb302e475f75c7b6b07f66a1a3