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Myeloablative Conditioning for Allogeneic Transplantation Results in Superior Disease-Free Survival for Acute Myelogenous Leukemia and Myelodysplastic Syndromes with Low/Intermediate but not High Disease Risk Index: A Center for International Blood and Marrow Transplant Research Study
- Source :
- Transplant Cell Ther, Transplantation and Cellular Therapy, 27(1). Elsevier
- Publication Year :
- 2020
-
Abstract
- Compared with reduced-intensity conditioning (RIC), myeloablative conditioning (MAC) is generally associated with lower relapse risk after allogeneic hematopoietic cell transplantation (HCT) for acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). However, disease-specific risk factors in AML/MDS can further inform when MAC and RIC may yield differential outcomes. We analyzed HCT outcomes stratified by the Disease Risk Index (DRI) in 4387 adults (age 40 to 65 years) to identify the impact of conditioning intensity. In the low/ intermediate-risk DRI cohort, RIC was associated with lower nonrelapse mortality (NRM) (hazard ratio [HR],.74; 95% confidence interval [CI],.62 to.88; P
- Subjects :
- Oncology
Transplantation Conditioning
IMPACT
medicine.medical_treatment
Hematopoietic stem cell transplantation
0302 clinical medicine
AML
hemic and lymphatic diseases
MDS
Immunology and Allergy
Medicine
610 Medicine & health
Myeloablative
Hazard ratio
Hematopoietic Stem Cell Transplantation
Hematology
Middle Aged
Leukemia
Leukemia, Myeloid, Acute
030220 oncology & carcinogenesis
WORKING PARTY
Molecular Medicine
REDUCED-INTENSITY
Adult
medicine.medical_specialty
Allogeneic transplantation
ACUTE MYELOID-LEUKEMIA
REGIMENS
Disease-Free Survival
Article
03 medical and health sciences
Myelogenous
Internal medicine
Humans
Transplantation, Homologous
TERM-FOLLOW-UP
Aged
Retrospective Studies
Transplantation
MUTATIONS
business.industry
Myelodysplastic syndromes
RIC
STEM-CELL TRANSPLANTATION
Cell Biology
medicine.disease
UNRELATED DONOR TRANSPLANTATION
Myelodysplastic Syndromes
DRI
business
030215 immunology
Subjects
Details
- ISSN :
- 26666367 and 26666375
- Volume :
- 27
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Transplantation and cellular therapy
- Accession number :
- edsair.doi.dedup.....a8f8b5ac3e5722c5cf5d6394f51c54d5