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Radiological and Clinical Patterns of Myeloid Sarcoma
- Source :
- Radiology and Oncology, Radiology and Oncology, Vol 53, Iss 2, Pp 213-218 (2019)
- Publication Year :
- 2019
- Publisher :
- Sciendo, 2019.
-
Abstract
- Background Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a solid tumor of extramedullary localization composed of malignant primitive myeloid cells. The purpose of the study was to identify clinical and imaging features in a large patient sample. Patients and methods Overall, 71 cases (34 females (47.9%) and 37 males (52.1%) with a median age of 56 (± 16 years) of histopathologically confirmed myeloid sarcoma were included into this study. The underlying hematological disease, occurrence, localizations and clinical symptoms as well as imaging features on computed tomography and magnetic resonance imaging were investigated. Results In 4 cases (5.63%) the manifestation of MS preceded the systemic hematological disease by a mean value of 3.8 ± 2.1 months. In 13 cases, first presentation of MS occurred simultaneously with the initial diagnosis of leukemia, and 51 patients presented MS after the initial diagnosis of the underlying malignancy with a mean latency of 39.8 ± 44.9 SD months. The visceral soft tissue was affected in 26 cases, followed by the cutis/subcutis was affected in 21 cases. Further localizations were bones (n = 13), central nervous system (n = 9), lymph nodes (n = 4) and visceral organs (n = 9). Conclusions MS is a rare complication of several hematological malignancies, predominantly of acute myeloid leukemia, which can affect any part of the body. In most cases it occurs after the diagnosis of the underlying malignancy, and affects frequently the cutis and subcutis.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Time Factors
Adolescent
R895-920
Cutis
Prodromal Symptoms
Malignancy
030218 nuclear medicine & medical imaging
Medical physics. Medical radiology. Nuclear medicine
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Myeloid sarcoma
myeloid sarcoma
Humans
Radiology, Nuclear Medicine and imaging
acute myeloid leukaemia
Sarcoma, Myeloid
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Myeloid leukemia
chloroma
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
granulocytic sarcoma
Leukemia
Leukemia, Myeloid, Acute
Oncology
030220 oncology & carcinogenesis
Female
Sarcoma
business
Complication
Tomography, X-Ray Computed
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15813207 and 13182099
- Volume :
- 53
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Radiology and Oncology
- Accession number :
- edsair.doi.dedup.....a8f523fd0bb630f2a694deb3a726d718