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Lactose Sensitivity and Lactose Malabsorption: The 2 Faces of Lactose Intolerance
- Source :
- Journal of Neurogastroenterology and Motility
- Publication Year :
- 2021
- Publisher :
- The Korean Society of Neurogastroenterology and Motility, 2021.
-
Abstract
- Background/aims Self-reported lactose intolerance (LI) is frequent in patients with functional bowel disorders (FBD) that could be interpreted as irritable bowel syndrome (IBS). The present study aims to characterize the responses of patients with FBD, without small intestinal bacterial overgrowth (SIBO), and LI, in terms of lactose malabsorption (LM) and lactose sensitivity (LS) according to psychological and clinical features. Methods One hundred and fifty-eight consecutive FBD outpatients with LI, and no SIBO, were classified according to the Rome III questionnaire and filled Beck Depression Inventory, and State and Trait Anxiety questionnaires. They underwent a lactose tolerance test in which glycemia during 60 minutes and digestive symptoms for 3 hours were recorded. Results Abnormal lactose tolerance tests were found in 110 patients (70%), 44 (28%) with LM, 96 (61%) with LS, and 30 (19%) having both LM and LS. LM patients had a higher frequency of functional diarrhea (P = 0.040) and a lower frequency of dysphagia (P = 0.031). LS patients had a higher depression score (P = 0.007), higher frequency of globus (P = 0.042), irritable bowel syndrome (IBS) (P = 0.027) and mixed IBS (P = 0.049), and lower frequency of abdominal pain (P = 0.040). LS was significantly associated with a higher depression score (P = 0.002), and a higher frequency of globus (P = 0.046). Conclusions Thirty percent of LI patients have normal lactose absorption and normal LS. In the other 70% of patients, LI could be associated with LM and/or LS.
- Subjects :
- Diarrhea
medicine.medical_specialty
Abdominal pain
Malabsorption
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Small intestinal bacterial overgrowth
medicine
Lactose
Irritable bowel syndrome
Lactose intolerance
business.industry
Beck Depression Inventory
medicine.disease
chemistry
030220 oncology & carcinogenesis
Original Article
030211 gastroenterology & hepatology
Neurology (clinical)
medicine.symptom
business
Subjects
Details
- ISSN :
- 20930887 and 20930879
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Journal of Neurogastroenterology and Motility
- Accession number :
- edsair.doi.dedup.....a8ed3e7c7907638034aecf4f27ce8af0