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Monitoring the Isothermal Dehydration of Crystalline Hydrates Using Low-Frequency Raman Spectroscopy
- Source :
- Molecular Pharmaceutics. 18:1264-1276
- Publication Year :
- 2021
- Publisher :
- American Chemical Society (ACS), 2021.
-
Abstract
- Detection of the solid-state forms of pharmaceutical compounds is important from the drug performance point of view. Low-frequency Raman (LFR) spectroscopy has been demonstrated to be very sensitive in detecting the different solid-state forms of pharmaceutically relevant compounds. The potential of LFR spectroscopy to probe the in situ isothermal dehydration was studied using piroxicam monohydrate (PXM) and theophylline monohydrate (TPMH) as the model drugs. The dehydration of PXM and TPMH at four different temperatures (95, 100, 105, and 110 °C and 50, 60, 70, and 80 °C, respectively) was monitored in both the low- (20-300 cm
- Subjects :
- Materials science
Analytical chemistry
Pharmaceutical Science
02 engineering and technology
Low frequency
Spectrum Analysis, Raman
Piroxicam
030226 pharmacology & pharmacy
Isothermal process
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Theophylline
Drug Discovery
medicine
Dehydration
Spectroscopy
Temperature
021001 nanoscience & nanotechnology
medicine.disease
Pharmaceutical Preparations
symbols
Molecular Medicine
Crystallization
0210 nano-technology
Raman spectroscopy
medicine.drug
Subjects
Details
- ISSN :
- 15438392 and 15438384
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Molecular Pharmaceutics
- Accession number :
- edsair.doi.dedup.....a8ed231a79350d13492cd94acfc0e82c