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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Authors :
Samuel Kuperman
Leila Karhunen
Geòrgia Escaramís
Sébastien Guillaume
Kelly L. Klump
David C. Whiteman
Colin A. Hodgkinson
Stephanie H. Witt
Artemis Tsitsika
Hana Papezova
Renato Polimanti
P. Eline Slagboom
Peter Zill
Jakob Grove
Toni-Kim Clarke
Michael Soyka
Jennifer Jordan
Steven Gallinger
Philip Gorwood
Preben Bo Mortensen
Yuri Milaneschi
Ingrid Meulenbelt
Jen Chyong Wang
Markus M. Nöthen
Katrin Männik
Henry R. Kranzler
Michael M. Vanyukov
Anna Keski-Rahkonen
William G. Iacono
Raymond K. Walters
Stephanie Le Hellard
Bochao Danae Lin
Vesna Boraska Perica
Marion Roberts
Patrick F. Sullivan
Steven Crawford
Mark A. Frye
Melissa A. Munn-Chernoff
Hakon Hakonarson
Andreas Birgegård
Robert Culverhouse
Alexis C. Edwards
Jerome C. Foo
Alessandro Rotondo
Brenda W.J.H. Penninx
Laura M. Hack
Michael T. Lynskey
Mario Maj
Alessio Maria Monteleone
Ted Reichborn-Kjennerud
Julie K. O'Toole
Marta Tyszkiewicz-Nwafor
Matt McGue
Julien Bryois
Martina de Zwaan
Norbert Dahmen
Stefanie Heilmann-Heimbach
Deborah Kaminská
Benedetta Nacmias
Nicholas G. Martin
Anna R. Docherty
Christopher Hübel
Nancy L. Pedersen
Janet Treasure
William E. Copeland
Roger A.H. Adan
Jaakko Kaprio
Aarno Palotie
L. John Horwood
Maria La Via
Philippe Courtet
Virpi M. Leppä
Judy L. Silberg
Jason D. Boardman
Fazil Aliev
Wade H. Berrettini
Doo Sup Choi
Youl-Ri Kim
Konstantinos Hatzikotoulas
Harriet de Wit
Sandra A. Brown
Elisabeth Widen
Caroline Hayward
Nicholas J. Schork
Penelope A. Lind
Ralph E. Tarter
Jana Strohmaier
Allan S. Kaplan
Richard A. Grucza
Bradley T. Webb
Angela Favaro
Dalila Pinto
Helena Gaspar
Andrew W. Bergen
Beate Herpertz-Dahlmann
Robert Levitan
Wolfgang Gäbel
Xavier Estivill
Emma C. Johnson
Konstantinos Tziouvas
Lindsay A. Farrer
Lenka Foretova
Marc A. Schuckit
Joanna M. Biernacka
André Scherag
Robbee Wedow
Abraham A. Palmer
Amy E. Adkins
Franziska Degenhardt
Louisa Degenhardt
Jurjen J. Luykx
Marius Lahti-Pulkkinen
Brien P. Riley
Monika Ridinger
Matteo Cassina
Harry Brandt
Yiran Guo
Stephan Ripke
Palmiero Monteleone
Katri Räikkönen
Jonathan R. I. Coleman
Martin A. Kennedy
Stephen W. Scherer
Ioanna Tachmazidou
Catherine M. Olsen
Bernice Porjesz
Esther Walton
Yi-Ling Chou
Nicolas Ramoz
Tetsuya Ando
Andres Metspalu
Bertram Müller-Myhsok
Brion S. Maher
Sarah Bertelsen
Melanie L. Schwandt
Janiece E. DeSocio
Margaret Keyes
John F. Pearson
Dongbing Lai
Paul Lichtenstein
James MacKillop
George Dedoussis
Jari Lahti
Ulrike Schmidt
Stefan Ehrlich
Amanda G. Wills
Teemu Palviainen
David Goldman
Elena Tenconi
Dimitris Dikeos
Scott I. Vrieze
Sietske G. Helder
Katharina Buehren
Hongyu Zhao
Sara McDevitt
Jolanta Lissowska
Joseph M. Boden
Li-Shiun Chen
Susanne Lucae
Sara Marsal
Dan Rujescu
Claes Norring
Howard J. Edenberg
Victor M. Karpyak
Fragiskos Gonidakis
Per Hoffmann
Christopher S. Franklin
Karin Egberts
Johanna Giuranna
Stefan Herms
Leah Wetherill
Stephanie Zerwas
Anthony Batzler
Elliot C. Nelson
Jouke-Jan Hottenga
Marcella Rietschel
Ioanna Ntalla
Victor Hesselbrock
Sarah M. Hartz
Marie Navratilova
Falk Kiefer
Martien J H Kas
Richard J. Rose
Andrew C. Heath
Jin P. Szatkiewicz
Lenka Slachtova
Lisa Lilenfeld
Katherine A. Halmi
John P. Rice
Anjali K. Henders
Christian Dina
Norbert Wodarz
Satu Männistö
Hamdi Mbarek
Shuyang Yao
Vladimir Janout
Alison Goate
Bettina Konte
Alexandra Schosser
Danfeng Chen
Kirsty Kiezebrink
Euijung Ryu
Dana B. Hancock
James Mitchell
Sarah E. Medland
Ina Giegling
Valdo Ricca
Scott D. Gordon
Gabrielle Koller
Samuli Ripatti
Laura M. Thornton
Alison D. Murray
Morten Mattingsdal
Zeynep Yilmaz
Jens Treutlein
Kathleen K. Bucholz
Tim B. Bigdeli
Eric F. van Furth
Hermine H. Maes
Ken B. Hanscombe
Sandra Sanchez-Roige
Daniela Degortes
Monica Forzan
Manuel Mattheisen
Richard Sherva
Scott J. Crow
Mikael Landén
Wolfgang Herzog
Jeanette N. McClintick
Tõnu Esko
Louis Fox
Wolfgang Maier
Liselotte Petersen
Laura J. Bierut
Roseann E. Peterson
Gursharan Kalsi
Kathleen Mullan Harris
Margarita C T Slof-Op 't Landt
Tamara L. Wall
Patrik K. E. Magnusson
Unna N. Danner
Stephan Zipfel
Ulrich W. Preuss
Elisa Docampo
D. Blake Woodside
Alfonso Tortorella
Benjamin W. Domingue
Franziska Ritschel
Johan G. Eriksson
Anu Raevuori
Benjamin M. Neale
Marcus Ising
Annemarie A. van Elburg
Filip Rybakowski
Maureen Reynolds
Tracey D. Wade
Manfred M. Fichter
Monica Gratacos Mayora
Claudette Boni
Andreas J. Forstner
John Whitfield
Silviu Alin Bacanu
Matthew B. McQueen
Andrew M. McIntosh
Norbert Scherbaum
Tatiana Foroud
Gun Peggy Knudsen
Sven Cichon
Christian J. Hopfer
Josef Frank
Eleftheria Zeggini
Federica Tozzi
Nadia Micali
Danielle M. Dick
Pamela A. F. Madden
Christian R. Marshall
Johannes Hebebrand
Fernando Fernández-Aranda
Roel A. Ophoff
Roland Burghardt
Nathaniel Thomas
Leonid Padyukov
Nancy L. Saccone
Anu Loukola
Fabian Streit
James L. Kennedy
Jessica H. Baker
Peter McGuffin
Walter H. Kaye
Pei Hong Shen
Anne Farmer
Roger D. Cone
Ilka Boehm
Jacquelyn L. Meyers
Paolo Santonastaso
Maurizio Clementi
Susana Jiménez-Murcia
Gudrun Wagner
Anke Hinney
Richard Parker
James I. Hudson
Nathan A. Gillespie
Michael Strober
John I. Nurnberger
Sandro Sorbi
Dorret I. Boomsma
Beata Świątkowska
Janne Tidselbak Larsen
Kenneth S. Kendler
Hidetoshi Inoko
Jessica E. Salvatore
Hunna J. Watson
Jochen Seitz
Jacques Pantel
Karl Mann
Hang Zhou
Antonio Julià
Oliver S. P. Davis
Nancy Diazgranados
Krista Fischer
John K. Hewitt
Karen S. Mitchell
Joanna Hauser
Eric O. Johnson
Craig Johnson
E. Jane Costello
Agnieszka Słopień
Dong Li
Laramie E. Duncan
Arpana Agrawal
Grant W. Montgomery
Manuel Föcker
Thomas Werge
Lannie Ligthart
Andreas Karwautz
Raquel Rabionet
Kenneth Krauter
Joel Gelernter
James J. Crowley
Cynthia M. Bulik
Paola Giusti-Rodríguez
Laura M. Huckins
Gerome Breen
Michael C. Stallings
Daniel E. Adkins
Pierre J. Magistretti
John Kramer
Lars Alfredsson
Hartmut Imgart
Annette M. Hartmann
Ole A. Andreassen
Monika Dmitrzak-Weglarz
Psychiatry
University of North Carolina [Chapel Hill] (UNC)
University of North Carolina System (UNC)
Department Psychiatry [Chapel Hill]
University of North Carolina System (UNC)-University of North Carolina System (UNC)
Washington University School of Medicine in St. Louis
Washington University in Saint Louis (WUSTL)
Institute of Psychiatry, Psychology & Neuroscience, King's College London
King‘s College London
Harvard Medical School [Boston] (HMS)
Broad Institute of MIT and Harvard (BROAD INSTITUTE)
Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston]
QIMR Berghofer Medical Research Institute
Karolinska Institutet [Stockholm]
University Children's Hospital of Essen [Essen, Germany]
University of Duisburg-Essen
Aarhus University [Aarhus]
Stockholm County Council
University of Würzburg
Guy's Hospital [London]
University Medical Center [Utrecht]
University of Gothenburg (GU)
Altrecht Center for Eating Disorders Rintveld [Zeist, The Netherlands] (Mental Health Institute)
National Institute of Mental Health [Tokyo, Japan] (NIMH)
National Center of Neurology and Psychiatry [Tokyo, Japan]
University of Oslo (UiO)
Norwegian Centre for Mental Disorders Research [Oslo] (NORMENT)
University of Oslo (UiO)-Haukeland University Hospital
University of Bergen (UiB)-University of Bergen (UiB)-Oslo University Hospital [Oslo]
Department of Psychiatry [Philadelphia]
University of Pennsylvania [Philadelphia]
Perelman School of Medicine
Technische Universität Dresden = Dresden University of Technology (TU Dresden)
Institut de psychiatrie et neurosciences (U894 / UMS 1266)
Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)
University of Split
The Wellcome Trust Sanger Institute [Cambridge]
RWTH Aachen University
Universitätsklinikum Frankfurt
Universita degli Studi di Padova
University Hospital Basel [Basel]
Jülich Supercomputing Centre (JSC)
Forschungszentrum Jülich GmbH | Centre de recherche de Juliers
Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association
Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC)
Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
University of Minnesota System
University of Bristol [Bristol]
Hannover Medical School [Hannover] (MHH)
Harokopio University of Athens
Seattle University [Seattle]
Virginia Commonwealth University (VCU)
University of Athens Medical School [Athens]
unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX)
Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)
Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Poznan University of Medical Sciences [Poland] (PUMS)
Institute of Environmental Science and Technology [Barcelona] (ICTA)
Universitat Autònoma de Barcelona (UAB)
Massachusetts General Hospital [Boston]
Stanford University
MetaGenoPolis (MGP (US 1367))
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Estonian Genome and Medicine
University of Tartu
Universitat Pompeu Fabra [Barcelona] (UPF)
MRC Social, Genetic and Developmental Psychiatry Centre (SGDP)
The Institute of Psychiatry-King‘s College London
Department of Psychiatry (IDIBELL)
CIBERobn Fisiopatología de la Obesidad y Nutrición-University Hospital of Bellvitge
Ludwig-Maximilians-Universität München (LMU)
Infectious diseases division, Department of internal medicine
University of Münster
Masaryk Memorial Cancer Institute
Masaryk Memorial Cancer Institute (RECAMO)
Universitätsklinikum Bonn (UKB)
Familial Gastrointestinal Cancer Registry
Mount Sinai Hospital [Toronto, Canada] (MSH)
Medstar Research Institute
Universität Duisburg-Essen [Essen]
National and Kapodistrian University of Athens (NKUA)
Children’s Hospital of Philadelphia (CHOP )
The Center for Applied Genomics
Psychiatric Genetic Unit
Poznan University of Medical Sciences
Department of Child and Adolescent Psychiatry and Psychotherapy, LVR-Klinikum Essen
Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health Leeds
University of Leeds
Rheinisch-Westfälische Technische Hochschule Aachen (RWTH)
Heidelberg University Hospital [Heidelberg]
Icahn School of Medicine at Mount Sinai [New York] (MSSM)
School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
Parkland-Klinik [Bad Wildungen-Reinhardshausen, Germany]
Tokai University
Department of Epidemiology and Public Health [university of Ostrava]
Lékařská fakulta / Faculty of Medicine [University of Ostrava]
Ostravská univerzita / University of Ostrava-Ostravská univerzita / University of Ostrava
Vall d'Hebron University Hospital [Barcelona]
Charles University [Prague] (CU)
University of Eastern Finland
Medizinische Universität Wien = Medical University of Vienna
Centre de toxicomanie et de santé mentale [Toronto, ON, Canada]
University of Helsinki
University of Aberdeen
Faculty of Science, J.E. Purkinje University
J. E. Purkinje University
Michigan State University System
Norwegian Institute of Public Health [Oslo] (NIPH)
Haukeland University Hospital
University of Bergen (UiB)
Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA)
Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
The Chicago School of Professional Psychology [Washington, District of Columbia, USA] (Washington DC Campus)
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
Brain and Mind Institute
Ecole Polytechnique Fédérale de Lausanne (EPFL)
Department of Psychiatry
University of Napoli
Center for Integrative Genomics - Institute of Bioinformatics, Génopode (CIG)
Swiss Institute of Bioinformatics [Lausanne] (SIB)
Université de Lausanne (UNIL)-Université de Lausanne (UNIL)
Program in Genetics and Genomic Biology
Hospital for Sick Children-University of Toronto McLaughlin Centre
KG Jebsen Centre for Psychosis Research
University of Oslo (UiO)-Institute of Clinical Medicine-Oslo University Hospital [Oslo]
University College Cork (UCC)
Section Molecular Epidemiology, Leiden University Medical Center (LUMC)
Institute of Psychiatry
King's College
VA Boston Healthcare System
Università degli studi della Campania 'Luigi Vanvitelli'
Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)
Kartini Clinic [Portland, Oregon, USA]
University Medical Center [Utrecht]-Brain Center Rudolf Magnus
Head of Medical Sequencing
Vanderbilt University School of Medicine [Nashville]
The Hospital for sick children [Toronto] (SickKids)
Center for Genomic Regulation (CRG-UPF)
CIBER de Epidemiología y Salud Pública (CIBERESP)
Department of Medical Epidemiology and Biostatistics (MEB)
University of Pisa - Università di Pisa
Division of Psychiatric Genomics
Institute of Medical Informatics, Biometry and Epidemiology
Department of Molecular and Experimental Medicine, The Scripps Research Institute
The Scripps Research Institute
MRC Centre for Neuropsychiatric Genetics and Genomics
Cardiff University-Medical Research Council
Leiden University Medical Center (LUMC)
Center for Eating Disorders Ursula [Leiden, The Netherlands] (Rivierduinen)
Medical University of Łódź (MUL)
The Jackson Laboratory [Bar Harbor] (JAX)
Neurosciences Centre of Excellence in Drug Discovery
GlaxoSmithKline Research and Development
Utrecht University [Utrecht]
SURFACES
Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON)
Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Centre épigénétique et destin cellulaire (EDC (UMR_7216))
Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Human Genetics
Internal Medicine [Tuebingen, Germany]
Tuebingen University [Germany]
Oregon Research Institute (ORI)
University of Otago [Dunedin, Nouvelle-Zélande]
The Center for Eating Disorders at Sheppard Pratt [Baltimore, MD, USA]
Weill Medical College of Cornell University [New York]
Eating Recovery Center [Denver, CO, USA]
Centre for Addiction and Mental Health [Toronto, ON, Canada]
University of California [San Diego] (UC San Diego)
University of California
Jet Propulsion Laboratory (JPL)
NASA-California Institute of Technology (CALTECH)
David Geffen School of Medicine [Los Angeles]
University of California [Los Angeles] (UCLA)
University of California-University of California
Center for Genomic Medicine
Copenhagen University Hospital-Rigshospitalet [Copenhagen]
Copenhagen University Hospital
Institute of Medical Science [Toronto]
University of Toronto
Department of Psychiatry [Pittsburgh]
University of Pittsburgh School of Medicine
Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE)
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
Génétique des maladies multifactorielles (GMM)
Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS)
Sahlgrenska Academy at University of Gothenburg [Göteborg]
Department of Genomics
Yale University School of Medicine
Indiana University School of Medicine
Indiana University System
Mayo Clinic [Rochester]
Mayo Clinic
SUNY Downstate Medical Center
State University of New York (SUNY)
University of Edinburgh
Department of Genomics, Life and Brain Center
University of Bonn
University of Utah School of Medicine [Salt Lake City]
University of Heidelberg, Medical Faculty
Department of Psychiatry and Behavioral Sciences
Howard University College of Medicine
Department of Genomics [Bonn, Germany] (Institute of Human Genetics)
University of Bonn-Institute of Human Genetics [Bonn, Germany]
National Institutes of Health [Bethesda] (NIH)
National Institute on Alcohol Abuse and Alcoholism [Bethesda, MD, USA] (NIAAA)
Martin-Luther-University Halle-Wittenberg
Helsinki Institute of Life Science (HiLIFE)
Johns Hopkins Bloomberg School of Public Health [Baltimore]
Johns Hopkins University (JHU)
Vrije Universiteit Amsterdam [Amsterdam] (VU)
Mathematical Sciences Institute (MSI)
Australian National University (ANU)
University of Colorado [Boulder]
VU University Medical Center [Amsterdam]
Boston University School of Medicine (BUSM)
Boston University [Boston] (BU)
Universität Heidelberg [Heidelberg]
Department of Genetic Epidemiology in Psychiatry [Mannhein]
Universität Heidelberg [Heidelberg]-Central Institute of Mental Health Mannheim
Harvard University [Cambridge]
University of Colorado Anschutz [Aurora]
University of Vermont [Burlington]
University of New South Wales [Sydney] (UNSW)
University of Dusseldorf
Genetics and Pathology
Center for Human Genetic Research
Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston]
Heidelberg University
University of Iowa [Iowa City]
Vienna University of Technology (TU Wien)
Max Planck Institute of Psychiatry
Max-Planck-Gesellschaft
Department of Psychiatry and Psychotherapy
Rheinische Friedrich-Wilhelms-Universität Bonn
Chronic Disease Epidemiology and Prevention Unit
National Institute for Health and Welfare [Helsinki]
Translational Centre for Regenerative Medicine (TRM)
Department of Cell Therapy
Universität Leipzig [Leipzig]-Universität Leipzig [Leipzig]
Indiana University System-Indiana University System
University of Pittsburgh (PITT)
Pennsylvania Commonwealth System of Higher Education (PCSHE)
University of Regensburg
Rush University Medical Center [Chicago]
University of Utah
Duke University Medical Center
University of Illinois [Chicago] (UIC)
University of Illinois System
Department of Medical and Molecular Genetics
Dpt of Neuroscience [New York]
Laboratory of Neurogenetics
National Institutes of Health [Bethesda] (NIH)-National Institute on Alcohol Abuse and Alcoholism
Department of Health and Human Services
University of Connecticut (UCONN)
University of Colorado [Denver]
Research Triangle Institute International (RTI International)
McMaster University [Hamilton, Ontario]
CLinical Psychology
Department of Electrical and Computer Engineering [Montréal]
McGill University = Université McGill [Montréal, Canada]
Yale School of Public Health (YSPH)
Analytic and Translational Genetics Unit
Flinders University [Adelaide, Australia]
Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM)
Department of Public Health
Indiana University - Purdue University Indianapolis (IUPUI)
National Institute of Mental Health (NIMH)
University of Pennsylvania
Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH)
Università degli Studi di Padova = University of Padua (Unipd)
Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Unité de recherche de l'institut du thorax (ITX-lab)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)
Université de Nantes (UN)-Université de Nantes (UN)
King‘s College London-The Institute of Psychiatry
Westfälische Wilhelms-Universität Münster = University of Münster (WWU)
Masaryk Memorial Cancer Institute (MMCI)
Helsingin yliopisto = Helsingfors universitet = University of Helsinki
Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL)
Università degli studi della Campania 'Luigi Vanvitelli' = University of the Study of Campania Luigi Vanvitelli
Università degli Studi di Firenze = University of Florence (UniFI)
Department of Molecular Medicine [Scripps Research Institute]
The Scripps Research Institute [La Jolla, San Diego]
Medical Research Council-Cardiff University
Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
University of California (UC)
University of California (UC)-University of California (UC)
Yale School of Medicine [New Haven, Connecticut] (YSM)
Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
Martinez Rico, Clara
Biological Psychology
APH - Health Behaviors & Chronic Diseases
APH - Personalized Medicine
APH - Mental Health
APH - Methodology
Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep
Amsterdam Neuroscience - Complex Trait Genetics
APH - Digital Health
Kas lab
Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
Munn-Chernoff, M. A.
Johnson, E. C.
Chou, Y. -L.
Coleman, J. R. I.
Thornton, L. M.
Walters, R. K.
Yilmaz, Z.
Baker, J. H.
Hubel, C.
Gordon, S.
Medland, S. E.
Watson, H. J.
Gaspar, H. A.
Bryois, J.
Hinney, A.
Leppa, V. M.
Mattheisen, M.
Ripke, S.
Yao, S.
Giusti-Rodriguez, P.
Hanscombe, K. B.
Adan, R. A. H.
Alfredsson, L.
Ando, T.
Andreassen, O. A.
Berrettini, W. H.
Boehm, I.
Boni, C.
Boraska Perica, V.
Buehren, K.
Burghardt, R.
Cassina, M.
Cichon, S.
Clementi, M.
Cone, R. D.
Courtet, P.
Crow, S.
Crowley, J. J.
Danner, U. N.
Davis, O. S. P.
de Zwaan, M.
Dedoussis, G.
Degortes, D.
Desocio, J. E.
Dick, D. M.
Dikeos, D.
Dina, C.
Dmitrzak-Weglarz, M.
Docampo, E.
Duncan, L. E.
Egberts, K.
Ehrlich, S.
Escaramis, G.
Esko, T.
Estivill, X.
Farmer, A.
Favaro, A.
Fernandez-Aranda, F.
Fichter, M. M.
Fischer, K.
Focker, M.
Foretova, L.
Forstner, A. J.
Forzan, M.
Franklin, C. S.
Gallinger, S.
Giegling, I.
Giuranna, J.
Gonidakis, F.
Gorwood, P.
Gratacos Mayora, M.
Guillaume, S.
Guo, Y.
Hakonarson, H.
Hatzikotoulas, K.
Hauser, J.
Hebebrand, J.
Helder, S. G.
Herms, S.
Herpertz-Dahlmann, B.
Herzog, W.
Huckins, L. M.
Hudson, J. I.
Imgart, H.
Inoko, H.
Janout, V.
Jimenez-Murcia, S.
Julia, A.
Kalsi, G.
Kaminska, D.
Karhunen, L.
Karwautz, A.
Kas, M. J. H.
Kennedy, J. L.
Keski-Rahkonen, A.
Kiezebrink, K.
Kim, Y. -R.
Klump, K. L.
Knudsen, G. P. S.
La Via, M. C.
Le Hellard, S.
Levitan, R. D.
Li, D.
Lilenfeld, L.
Lin, B. D.
Lissowska, J.
Luykx, J.
Magistretti, P. J.
Maj, M.
Mannik, K.
Marsal, S.
Marshall, C. R.
Mattingsdal, M.
Mcdevitt, S.
Mcguffin, P.
Metspalu, A.
Meulenbelt, I.
Micali, N.
Mitchell, K.
Monteleone, A. M.
Monteleone, P.
Nacmias, B.
Navratilova, M.
Ntalla, I.
O'Toole, J. K.
Ophoff, R. A.
Padyukov, L.
Palotie, A.
Pantel, J.
Papezova, H.
Pinto, D.
Rabionet, R.
Raevuori, A.
Ramoz, N.
Reichborn-Kjennerud, T.
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Addiction Biology, 26(1):e12880. Wiley-Blackwell, Addiction Biology, Addiction Biology, Wiley, 2020, 40, pp.e12880. ⟨10.1111/adb.12880⟩, 2021, ' Shared Genetic Risk between Eating Disorder-and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies ', Addiction Biology, vol. 26, no. 1, e12880 . https://doi.org/10.1111/adb.12880, Munn-Chernoff, M A, Johnson, E C, Chou, Y L, Coleman, J R I, Thornton, L M, Walters, R K, Yilmaz, Z, Baker, J H, Hübel, C, Gordon, S, Medland, S E, Watson, H J, Gaspar, H A, Bryois, J, Hinney, A, Leppä, V M, Mattheisen, M, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, K B, Adan, R A H, Alfredsson, L, Ando, T, Andreassen, O A, Berrettini, W H, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, R D, Courtet, P, Crow, S, Farmer, A, Helder, S G, Kalsi, G, McGuffin, P, Roberts, M, Schmidt, U, Treasure, J, Walton, E, Lynskey, M T, Madden, P A F, Riley, B P, Neale, B M & Breen, G 2021, ' Shared genetic risk between eating disorder-and substance-use-related phenotypes : Evidence from genome-wide association studies ', Addiction Biology, vol. 26, no. 1, e12880 . https://doi.org/10.1111/adb.12880, Addiction Biology, 2020, 40, pp.e12880. ⟨10.1111/adb.12880⟩, Addiction Biology, 26(1):e12880, 1-20. Wiley-Blackwell, ADDICT BIOL, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, Addict Biol, ADDICTION BIOLOGY, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, Addiction Biology, 26(1). WILEY, Addiction biology, 26(1):e12880. 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Giusti-Rodríguez, P, Hanscombe, K B, Adan, R A H, Alfredsson, L, Ando, T, Andreassen, O A, Berrettini, W H, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, R D, Courtet, P, Crow, S, Crowley, J J, Danner, U N, Davis, O S P, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, J E, Dick, D M, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, L E, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Estivill, X, Farmer, A, Favaro, A, Fernández-Aranda, F, Fichter, M M, Fischer, K, Föcker, M, Foretova, L, Forstner, A J, Forzan, M, Franklin, C S, Gallinger, S, Giegling, I, Giuranna, J, Gonidakis, F, Gorwood, P, Gratacos Mayora, M, Guillaume, S, Guo, Y, Hakonarson, H, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, S G, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Huckins, L M, Hudson, J I, Imgart, H, Inoko, H, Janout, V, Jiménez-Murcia, S, Julià, A, Kalsi, G, Kaminská, D, Karhunen, L, Karwautz, A, Kas, M J H, Kennedy, J L, Keski-Rahkonen, A, Kiezebrink, K, Kim, Y-R, Klump, K L, Knudsen, G P S, La Via, M C, Le Hellard, S, Levitan, R D, Li, D, Lilenfeld, L, Lin, B D, Lissowska, J, Luykx, J, Magistretti, P J, Maj, M, Mannik, K, Marsal, S, Marshall, C R, Mattingsdal, M, McDevitt, S, McGuffin, P, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, K, Monteleone, A M, Monteleone, P, Nacmias, B, Navratilova, M, Ntalla, I, O'Toole, J K, Ophoff, R A, Padyukov, L, Palotie, A, Pantel, J, Papezova, H, Pinto, D, Rabionet, R, Raevuori, A, Ramoz, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, S W, Schmidt, U, Schork, N J, Schosser, A, Seitz, J, Slachtova, L, Slagboom, P E, Slof-Op't Landt, M C T, Slopien, A, Sorbi, S, Świątkowska, B, Szatkiewicz, J P, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tsitsika, A, Tyszkiewicz-Nwafor, M, Tziouvas, K, van Elburg, A A, van Furth, E F, Wagner, G, Walton, E, Widen, E, Zeggini, E, Zerwas, S, Zipfel, S, Bergen, A W, Boden, J M, Brandt, H, Crawford, S, Halmi, K A, Horwood, L J, Johnson, C, Kaplan, A S, Kaye, W H, Mitchell, J, Olsen, C M, Pearson, J F, Pedersen, N L, Strober, M, Werge, T, Whiteman, D C, Woodside, D B, Grove, J, Henders, A K, Larsen, J T, Parker, R, Petersen, L V, Jordan, J, Kennedy, M A, Birgegård, A, Lichtenstein, P, Norring, C, Landén, M, Mortensen, P B, Polimanti, R, McClintick, J N, Adkins, A E, Aliev, F, Bacanu, S-A, Batzler, A, Bertelsen, S, Biernacka, J M, Bigdeli, T B, Chen, L-S, Clarke, T-K, Degenhardt, F, Docherty, A R, Edwards, A C, Foo, J C, Fox, L, Frank, J, Hack, L M, Hartmann, A M, Hartz, S M, Heilmann-Heimbach, S, Hodgkinson, C, Hoffmann, P, Hottenga, J-J, Konte, B, Lahti, J, Lahti-Pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, B S, Mbarek, H, McIntosh, A M, McQueen, M B, Meyers, J L, Milaneschi, Y, Palviainen, T, Peterson, R E, Ryu, E, Saccone, N L, Salvatore, J E, Sanchez-Roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, J-C, Webb, B T, Wedow, R, Wetherill, L, Wills, A G, Zhou, H, Boardman, J D, Chen, D, Choi, D-S, Copeland, W E, Culverhouse, R C, Dahmen, N, Degenhardt, L, Domingue, B W, Frye, M A, Gäbel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Koller, G, Kramer, J, Kuperman, S, Lucae, S, Lynskey, M T, Maier, W, Mann, K, Männistö, S, Müller-Myhsok, B, Murray, A D, Nurnberger, J I, Preuss, U, Räikkönen, K, Reynolds, M D, Ridinger, M, Scherbaum, N, Schuckit, M A, Soyka, M, Treutlein, J, Witt, S H, Wodarz, N, Zill, P, Adkins, D E, Boomsma, D I, Bierut, L J, Brown, S A, Bucholz, K K, Costello, E J, de Wit, H, Diazgranados, N, Eriksson, J G, Farrer, L A, Foroud, T M, Gillespie, N A, Goate, A M, Goldman, D, Grucza, R A, Hancock, D B, Harris, K M, Hesselbrock, V, Hewitt, J K, Hopfer, C J, Iacono, W G, Johnson, E O, Karpyak, V M, Kendler, K S, Kranzler, H R, Krauter, K, Lind, P A, McGue, M, MacKillop, J, Madden, P A F, Maes, H H, Magnusson, P K E, Nelson, E C, Nöthen, M M, Palmer, A A, Penninx, B W J H, Porjesz, B, Rice, J P, Rietschel, M, Riley, B P, Rose, R J, Shen, P-H, Silberg, J, Stallings, M C, Tarter, R E, Vanyukov, M M, Vrieze, S, Wall, T L, Whitfield, J B, Zhao, H, Neale, B M, Wade, T D, Heath, A C, Montgomery, G W, Martin, N G, Sullivan, P F, Kaprio, J, Breen, G, Gelernter, J, Edenberg, H J, Bulik, C M & Agrawal, A 2021, ' Shared genetic risk between eating disorder-and substance-use-related phenotypes : Evidence from genome-wide association studies ', Addiction Biology, vol. 26, no. 1, e12880, pp. 1-20 . https://doi.org/10.1111/adb.12880, Addiction Biology, Vol. 26, No 1 (2020) P. e12880
Publication Year :
2021

Abstract

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge-eating, AN without binge-eating, and a BN factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder (MDD). Total sample sizes per phenotype ranged from ~2,400 to ~537,000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg=0.18; false discovery rate q=0.0006), cannabis initiation and AN (rg=0.23; qwith binge-eating (rg=0.27; q=0.0016). Conversely, significant negative genetic correlations were observed between three non-diagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge-eating (rgs=-0.19 to −0.23; qs

Subjects

Subjects :
Netherlands Twin Register (NTR)
Alcoholism/genetics
Schizophrenia/genetics
[SDV]Life Sciences [q-bio]
[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Medizin
Medicine (miscellaneous)
Genome-wide association study
Alcohol use disorder
Anorexia nervosa
Linkage Disequilibrium
ddc:616.89
[SCCO]Cognitive science
0302 clinical medicine
Risk Factors
Tobacco Use Disorder/genetics
Substance-Related Disorders/genetics
0303 health sciences
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Factors de risc en les malalties
Bulimia nervosa
Feeding and Eating Disorders/genetics
eating disorders
genetic correlation
substance use
Tobacco Use Disorder
3. Good health
Fenotip
[SDV] Life Sciences [q-bio]
Psychiatry and Mental health
Alcoholism
Eating disorders
Phenotype
Schizophrenia
Drinking of alcoholic beverages
eating disorder
Consum d'alcohol
Major depressive disorder
medicine.symptom
Depressive Disorder, Major/genetics
eating disorders, genetic correlation, substance use
Clinical psychology
Substance abuse
Risk factors in diseases
Substance-Related Disorders
Polymorphism, Single Nucleotide
Article
Feeding and Eating Disorders
03 medical and health sciences
SDG 3 - Good Health and Well-being
mental disorders
Genetics
medicine
Humans
Trastorns de la conducta alimentària
030304 developmental biology
Genetic association
Pharmacology
Depressive Disorder, Major
Binge eating
business.industry
[SCCO.NEUR]Cognitive science/Neuroscience
[SCCO.NEUR] Cognitive science/Neuroscience
[SCCO] Cognitive science
medicine.disease
Comorbidity
Twin study
030227 psychiatry
Abús de substàncies
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
business
Genètica
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Genome-Wide Association Study

Details

Language :
English
ISSN :
13556215 and 13691600
Database :
OpenAIRE
Journal :
Addiction Biology, 26(1):e12880. Wiley-Blackwell, Addiction Biology, Addiction Biology, Wiley, 2020, 40, pp.e12880. ⟨10.1111/adb.12880⟩, 2021, ' Shared Genetic Risk between Eating Disorder-and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies ', Addiction Biology, vol. 26, no. 1, e12880 . https://doi.org/10.1111/adb.12880, Munn-Chernoff, M A, Johnson, E C, Chou, Y L, Coleman, J R I, Thornton, L M, Walters, R K, Yilmaz, Z, Baker, J H, Hübel, C, Gordon, S, Medland, S E, Watson, H J, Gaspar, H A, Bryois, J, Hinney, A, Leppä, V M, Mattheisen, M, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, K B, Adan, R A H, Alfredsson, L, Ando, T, Andreassen, O A, Berrettini, W H, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, R D, Courtet, P, Crow, S, Farmer, A, Helder, S G, Kalsi, G, McGuffin, P, Roberts, M, Schmidt, U, Treasure, J, Walton, E, Lynskey, M T, Madden, P A F, Riley, B P, Neale, B M & Breen, G 2021, ' Shared genetic risk between eating disorder-and substance-use-related phenotypes : Evidence from genome-wide association studies ', Addiction Biology, vol. 26, no. 1, e12880 . https://doi.org/10.1111/adb.12880, Addiction Biology, 2020, 40, pp.e12880. ⟨10.1111/adb.12880⟩, Addiction Biology, 26(1):e12880, 1-20. Wiley-Blackwell, ADDICT BIOL, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, Addict Biol, ADDICTION BIOLOGY, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, Addiction Biology, 26(1). WILEY, Addiction biology, 26(1):e12880. Wiley, Dipòsit Digital de la UB, Universidad de Barcelona, Munn-Chernoff, M A, Johnson, E C, Chou, Y L, Coleman, J R I, Thornton, L M, Walters, R K, Yilmaz, Z, Baker, J H, Hübel, C, Gordon, S, Medland, S E, Watson, H J, Gaspar, H A, Bryois, J, Hinney, A, Leppä, V M, Mattheisen, M, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, K B, Adan, R A H, Alfredsson, L, Ando, T, Andreassen, O A, Berrettini, W H, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, R D, Courtet, P, Crow, S, Crowley, J J, Danner, U N, Davis, O S P, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, J E, Dick, D M, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, L E, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Estivill, X, Farmer, A, Favaro, A, Fernández-Aranda, F, Fichter, M M, Fischer, K, Föcker, M, Foretova, L, Forstner, A J, Forzan, M, Franklin, C S, Gallinger, S, Giegling, I, Giuranna, J, Gonidakis, F, Gorwood, P, Gratacos Mayora, M, Guillaume, S, Guo, Y, Hakonarson, H, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, S G, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Huckins, L M, Hudson, J I, Imgart, H, Inoko, H, Janout, V, Jiménez-Murcia, S, Julià, A, Kalsi, G, Kaminská, D, Karhunen, L, Karwautz, A, Kas, M J H, Kennedy, J L, Keski-Rahkonen, A, Kiezebrink, K, Kim, Y R, Klump, K L, Knudsen, G P S, La Via, M C, Le Hellard, S, Levitan, R D, Li, D, Lilenfeld, L, Lin, B D, Lissowska, J, Luykx, J, Magistretti, P J, Maj, M, Mannik, K, Marsal, S, Marshall, C R, Mattingsdal, M, McDevitt, S, McGuffin, P, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, K, Monteleone, A M, Monteleone, P, Nacmias, B, Navratilova, M, Ntalla, I, O'Toole, J K, Ophoff, R A, Padyukov, L, Palotie, A, Pantel, J, Papezova, H, Pinto, D, Rabionet, R, Raevuori, A, Ramoz, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, S W, Schmidt, U, Schork, N J, Schosser, A, Seitz, J, Slachtova, L, Slagboom, P E, Slof-Op't Landt, M C T, Slopien, A, Sorbi, S, Świątkowska, B, Szatkiewicz, J P, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tsitsika, A, Tyszkiewicz-Nwafor, M, Tziouvas, K, van Elburg, A A, van Furth, E F, Wagner, G, Walton, E, Widen, E, Zeggini, E, Zerwas, S, Zipfel, S, Bergen, A W, Boden, J M, Brandt, H, Crawford, S, Halmi, K A, Horwood, L J, Johnson, C, Kaplan, A S, Kaye, W H, Mitchell, J, Olsen, C M, Pearson, J F, Pedersen, N L, Strober, M, Werge, T, Whiteman, D C, Woodside, D B, Grove, J, Henders, A K, Larsen, J T, Parker, R, Petersen, L V, Jordan, J, Kennedy, M A, Birgegård, A, Lichtenstein, P, Norring, C, Landén, M, Mortensen, P B, Polimanti, R, McClintick, J N, Adkins, A E, Aliev, F, Bacanu, S A, Batzler, A, Bertelsen, S, Biernacka, J M, Bigdeli, T B, Chen, L S, Clarke, T K, Degenhardt, F, Docherty, A R, Edwards, A C, Foo, J C, Fox, L, Frank, J, Hack, L M, Hartmann, A M, Hartz, S M, Heilmann-Heimbach, S, Hodgkinson, C, Hoffmann, P, Hottenga, J J, Konte, B, Lahti, J, Lahti-Pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, B S, Mbarek, H, McIntosh, A M, McQueen, M B, Meyers, J L, Milaneschi, Y, Palviainen, T, Peterson, R E, Ryu, E, Saccone, N L, Salvatore, J E, Sanchez-Roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, J C, Webb, B T, Wedow, R, Wetherill, L, Wills, A G, Zhou, H, Boardman, J D, Chen, D, Choi, D S, Copeland, W E, Culverhouse, R C, Dahmen, N, Degenhardt, L, Domingue, B W, Frye, M A, Gäbel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Koller, G, Kramer, J, Kuperman, S, Lucae, S, Lynskey, M T, Maier, W, Mann, K, Männistö, S, Müller-Myhsok, B, Murray, A D, Nurnberger, J I, Preuss, U, Räikkönen, K, Reynolds, M D, Ridinger, M, Scherbaum, N, Schuckit, M A, Soyka, M, Treutlein, J, Witt, S H, Wodarz, N, Zill, P, Adkins, D E, Boomsma, D I, Bierut, L J, Brown, S A, Bucholz, K K, Costello, E J, de Wit, H, Diazgranados, N, Eriksson, J G, Farrer, L A, Foroud, T M, Gillespie, N A, Goate, A M, Goldman, D, Grucza, R A, Hancock, D B, Harris, K M, Hesselbrock, V, Hewitt, J K, Hopfer, C J, Iacono, W G, Johnson, E O, Karpyak, V M, Kendler, K S, Kranzler, H R, Krauter, K, Lind, P A, McGue, M, MacKillop, J, Madden, P A F, Maes, H H, Magnusson, P K E, Nelson, E C, Nöthen, M M, Palmer, A A, Penninx, B W J H, Porjesz, B, Rice, J P, Rietschel, M, Riley, B P, Rose, R J, Shen, P H, Silberg, J, Stallings, M C, Tarter, R E, Vanyukov, M M, Vrieze, S, Wall, T L, Whitfield, J B, Zhao, H, Neale, B M, Wade, T D, Heath, A C, Montgomery, G W, Martin, N G, Sullivan, P F, Kaprio, J, Breen, G, Gelernter, J, Edenberg, H J, Bulik, C M & Agrawal, A 2021, ' Shared genetic risk between eating disorder-and substance-use-related phenotypes : Evidence from genome-wide association studies ', Addiction Biology, vol. 26, no. 1, e12880 . https://doi.org/10.1111/adb.12880, Munn-Chernoff, M A, Johnson, E C, Chou, Y-L, Coleman, J R I, Thornton, L M, Walters, R K, Yilmaz, Z, Baker, J H, Hübel, C, Gordon, S, Medland, S E, Watson, H J, Gaspar, H A, Bryois, J, Hinney, A, Leppä, V M, Mattheisen, M, Ripke, S, Yao, S, Giusti-Rodríguez, P, Hanscombe, K B, Adan, R A H, Alfredsson, L, Ando, T, Andreassen, O A, Berrettini, W H, Boehm, I, Boni, C, Boraska Perica, V, Buehren, K, Burghardt, R, Cassina, M, Cichon, S, Clementi, M, Cone, R D, Courtet, P, Crow, S, Crowley, J J, Danner, U N, Davis, O S P, de Zwaan, M, Dedoussis, G, Degortes, D, DeSocio, J E, Dick, D M, Dikeos, D, Dina, C, Dmitrzak-Weglarz, M, Docampo, E, Duncan, L E, Egberts, K, Ehrlich, S, Escaramís, G, Esko, T, Estivill, X, Farmer, A, Favaro, A, Fernández-Aranda, F, Fichter, M M, Fischer, K, Föcker, M, Foretova, L, Forstner, A J, Forzan, M, Franklin, C S, Gallinger, S, Giegling, I, Giuranna, J, Gonidakis, F, Gorwood, P, Gratacos Mayora, M, Guillaume, S, Guo, Y, Hakonarson, H, Hatzikotoulas, K, Hauser, J, Hebebrand, J, Helder, S G, Herms, S, Herpertz-Dahlmann, B, Herzog, W, Huckins, L M, Hudson, J I, Imgart, H, Inoko, H, Janout, V, Jiménez-Murcia, S, Julià, A, Kalsi, G, Kaminská, D, Karhunen, L, Karwautz, A, Kas, M J H, Kennedy, J L, Keski-Rahkonen, A, Kiezebrink, K, Kim, Y-R, Klump, K L, Knudsen, G P S, La Via, M C, Le Hellard, S, Levitan, R D, Li, D, Lilenfeld, L, Lin, B D, Lissowska, J, Luykx, J, Magistretti, P J, Maj, M, Mannik, K, Marsal, S, Marshall, C R, Mattingsdal, M, McDevitt, S, McGuffin, P, Metspalu, A, Meulenbelt, I, Micali, N, Mitchell, K, Monteleone, A M, Monteleone, P, Nacmias, B, Navratilova, M, Ntalla, I, O'Toole, J K, Ophoff, R A, Padyukov, L, Palotie, A, Pantel, J, Papezova, H, Pinto, D, Rabionet, R, Raevuori, A, Ramoz, N, Reichborn-Kjennerud, T, Ricca, V, Ripatti, S, Ritschel, F, Roberts, M, Rotondo, A, Rujescu, D, Rybakowski, F, Santonastaso, P, Scherag, A, Scherer, S W, Schmidt, U, Schork, N J, Schosser, A, Seitz, J, Slachtova, L, Slagboom, P E, Slof-Op't Landt, M C T, Slopien, A, Sorbi, S, Świątkowska, B, Szatkiewicz, J P, Tachmazidou, I, Tenconi, E, Tortorella, A, Tozzi, F, Treasure, J, Tsitsika, A, Tyszkiewicz-Nwafor, M, Tziouvas, K, van Elburg, A A, van Furth, E F, Wagner, G, Walton, E, Widen, E, Zeggini, E, Zerwas, S, Zipfel, S, Bergen, A W, Boden, J M, Brandt, H, Crawford, S, Halmi, K A, Horwood, L J, Johnson, C, Kaplan, A S, Kaye, W H, Mitchell, J, Olsen, C M, Pearson, J F, Pedersen, N L, Strober, M, Werge, T, Whiteman, D C, Woodside, D B, Grove, J, Henders, A K, Larsen, J T, Parker, R, Petersen, L V, Jordan, J, Kennedy, M A, Birgegård, A, Lichtenstein, P, Norring, C, Landén, M, Mortensen, P B, Polimanti, R, McClintick, J N, Adkins, A E, Aliev, F, Bacanu, S-A, Batzler, A, Bertelsen, S, Biernacka, J M, Bigdeli, T B, Chen, L-S, Clarke, T-K, Degenhardt, F, Docherty, A R, Edwards, A C, Foo, J C, Fox, L, Frank, J, Hack, L M, Hartmann, A M, Hartz, S M, Heilmann-Heimbach, S, Hodgkinson, C, Hoffmann, P, Hottenga, J-J, Konte, B, Lahti, J, Lahti-Pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, B S, Mbarek, H, McIntosh, A M, McQueen, M B, Meyers, J L, Milaneschi, Y, Palviainen, T, Peterson, R E, Ryu, E, Saccone, N L, Salvatore, J E, Sanchez-Roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, J-C, Webb, B T, Wedow, R, Wetherill, L, Wills, A G, Zhou, H, Boardman, J D, Chen, D, Choi, D-S, Copeland, W E, Culverhouse, R C, Dahmen, N, Degenhardt, L, Domingue, B W, Frye, M A, Gäebel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Koller, G, Kramer, J, Kuperman, S, Lucae, S, Lynskey, M T, Maier, W, Mann, K, Männistö, S, Müller-Myhsok, B, Murray, A D, Nurnberger, J I, Preuss, U, Räikkönen, K, Reynolds, M D, Ridinger, M, Scherbaum, N, Schuckit, M A, Soyka, M, Treutlein, J, Witt, S H, Wodarz, N, Zill, P, Adkins, D E, Boomsma, D I, Bierut, L J, Brown, S A, Bucholz, K K, Costello, E J, de Wit, H, Diazgranados, N, Eriksson, J G, Farrer, L A, Foroud, T M, Gillespie, N A, Goate, A M, Goldman, D, Grucza, R A, Hancock, D B, Harris, K M, Hesselbrock, V, Hewitt, J K, Hopfer, C J, Iacono, W G, Johnson, 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