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External Validation of a Multiparametric Magnetic Resonance Imaging–based Nomogram for the Prediction of Extracapsular Extension and Seminal Vesicle Invasion in Prostate Cancer Patients Undergoing Radical Prostatectomy

External Validation of a Multiparametric Magnetic Resonance Imaging–based Nomogram for the Prediction of Extracapsular Extension and Seminal Vesicle Invasion in Prostate Cancer Patients Undergoing Radical Prostatectomy

Authors :
Giuseppe Simone
Julien Van Damme
Grégoire Assenmacher
Thierry Roumeguere
Alexandre Peltier
Mathieu Roumiguié
Marco Oderda
Thierry Quackels
Guillaume Ploussard
Romain Diamand
Gaelle Fiard
Daniel Benamran
Jean-Luc Descotes
Christophe Iselin
Jean-Baptiste Roche
Simone Albisinni
Bernard Malavaud
UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale
UCL - (SLuc) Service d'urologie
Source :
European Urology, Vol. 79, No 2 (2021) pp. 180-185, European urology, Vol. 79, no.2, p. 180-185 (2021)
Publication Year :
2021

Abstract

The nomogram reported by Gandaglia et al (The key combined value of multiparametric magnetic resonance imaging, and magnetic resonance imaging-targeted and concomitant systematic biopsies for the prediction of adverse pathological features in prostate cancer patients undergoing radical prostatectomy. Eur Urol 2020;77:733-41) predicting extracapsular extension (ECE) or seminal vesicle invasion (SVI) has been developed using multiparametric magnetic resonance imaging (MRI) parameters and MRI-targeted biopsy. We aimed to validate this nomogram externally by analyzing 566 patients harboring prostate cancer diagnosed on MRI-targeted biopsy followed by radical prostatectomy. At final pathology, 37% and 12% patients had ECE and SVI, respectively. Performance of the nomogram, in comparison with the Memorial Sloan Kettering Cancer Center (MSKCC) model and Partin tables, was evaluated using discrimination, calibration, and decision curve analysis. Regarding ECE prediction, the nomogram showed higher discrimination (71.8% vs 69.8%, p = 0.3 and 71.8% vs 61.3%, p

Details

Language :
English
ISSN :
03022838
Database :
OpenAIRE
Journal :
European Urology, Vol. 79, No 2 (2021) pp. 180-185, European urology, Vol. 79, no.2, p. 180-185 (2021)
Accession number :
edsair.doi.dedup.....a8e67133d4c5fc36e3f37bb83da48d15