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External Validation of a Multiparametric Magnetic Resonance Imaging–based Nomogram for the Prediction of Extracapsular Extension and Seminal Vesicle Invasion in Prostate Cancer Patients Undergoing Radical Prostatectomy
External Validation of a Multiparametric Magnetic Resonance Imaging–based Nomogram for the Prediction of Extracapsular Extension and Seminal Vesicle Invasion in Prostate Cancer Patients Undergoing Radical Prostatectomy
- Source :
- European Urology, Vol. 79, No 2 (2021) pp. 180-185, European urology, Vol. 79, no.2, p. 180-185 (2021)
- Publication Year :
- 2021
-
Abstract
- The nomogram reported by Gandaglia et al (The key combined value of multiparametric magnetic resonance imaging, and magnetic resonance imaging-targeted and concomitant systematic biopsies for the prediction of adverse pathological features in prostate cancer patients undergoing radical prostatectomy. Eur Urol 2020;77:733-41) predicting extracapsular extension (ECE) or seminal vesicle invasion (SVI) has been developed using multiparametric magnetic resonance imaging (MRI) parameters and MRI-targeted biopsy. We aimed to validate this nomogram externally by analyzing 566 patients harboring prostate cancer diagnosed on MRI-targeted biopsy followed by radical prostatectomy. At final pathology, 37% and 12% patients had ECE and SVI, respectively. Performance of the nomogram, in comparison with the Memorial Sloan Kettering Cancer Center (MSKCC) model and Partin tables, was evaluated using discrimination, calibration, and decision curve analysis. Regarding ECE prediction, the nomogram showed higher discrimination (71.8% vs 69.8%, p = 0.3 and 71.8% vs 61.3%, p
- Subjects :
- Male
medicine.medical_specialty
Urology
medicine.medical_treatment
030232 urology & nephrology
External validation
Extracapsular extension
Nomogram
Prostate cancer
Seminal vesicle invasion
Aged
Humans
Middle Aged
Neoplasm Invasiveness
Prostatectomy
Prostatic Neoplasms
Seminal Vesicles
Extranodal Extension
Multiparametric Magnetic Resonance Imaging
Nomograms
03 medical and health sciences
0302 clinical medicine
Biopsy
medicine
medicine.diagnostic_test
ddc:617
business.industry
Magnetic resonance imaging
medicine.disease
Settore MED/24
030220 oncology & carcinogenesis
Concomitant
Partin Tables
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 03022838
- Database :
- OpenAIRE
- Journal :
- European Urology, Vol. 79, No 2 (2021) pp. 180-185, European urology, Vol. 79, no.2, p. 180-185 (2021)
- Accession number :
- edsair.doi.dedup.....a8e67133d4c5fc36e3f37bb83da48d15