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KinMap: a web-based tool for interactive navigation through human kinome data
- Source :
- BMC Bioinformatics
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Background Annotations of the phylogenetic tree of the human kinome is an intuitive way to visualize compound profiling data, structural features of kinases or functional relationships within this important class of proteins. The increasing volume and complexity of kinase-related data underlines the need for a tool that enables complex queries pertaining to kinase disease involvement and potential therapeutic uses of kinase inhibitors. Results Here, we present KinMap, a user-friendly online tool that facilitates the interactive navigation through kinase knowledge by linking biochemical, structural, and disease association data to the human kinome tree. To this end, preprocessed data from freely-available sources, such as ChEMBL, the Protein Data Bank, and the Center for Therapeutic Target Validation platform are integrated into KinMap and can easily be complemented by proprietary data. The value of KinMap will be exemplarily demonstrated for uncovering new therapeutic indications of known kinase inhibitors and for prioritizing kinases for drug development efforts. Conclusion KinMap represents a new generation of kinome tree viewers which facilitates interactive exploration of the human kinome. KinMap enables generation of high-quality annotated images of the human kinome tree as well as exchange of kinome-related data in scientific communications. Furthermore, KinMap supports multiple input and output formats and recognizes alternative kinase names and links them to a unified naming scheme, which makes it a useful tool across different disciplines and applications. A web-service of KinMap is freely available at http://www.kinhub.org/kinmap/. Electronic supplementary material The online version of this article (doi:10.1186/s12859-016-1433-7) contains supplementary material, which is available to authorized users.
- Subjects :
- Models, Molecular
0301 basic medicine
Scheme (programming language)
Biology
Biochemistry
03 medical and health sciences
0302 clinical medicine
Protein kinases
Structural Biology
Carcinoma, Non-Small-Cell Lung
Interactive annotation
Humans
Web application
Kinome
Human kinome tree
Databases, Protein
Protein Kinase Inhibitors
Molecular Biology
Phylogeny
computer.programming_language
Internet
Class (computer programming)
Information retrieval
business.industry
Applied Mathematics
Molecular Sequence Annotation
computer.file_format
chEMBL
Protein Data Bank
Data science
Computer Science Applications
Tree (data structure)
030104 developmental biology
Drug Design
030220 oncology & carcinogenesis
Images
The Internet
business
computer
Software
Subjects
Details
- ISSN :
- 14712105
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Bioinformatics
- Accession number :
- edsair.doi.dedup.....a8dea7d8080f3a1038e559b3a83c6d32