PReS-FINAL-2350: Overexpression of crem alpha leads to a higher inflammatory response in lps induced acute lung injury (ali) and might therefore trigger infectious complications in patients with autoimmune diseases

Patients with autoimmune diseases are highly susceptible towards infectious complications. In patients with SLE, infections are even one of the most common causes of morbidity, hospitalization and death. CREMα is a transcription factor, which is overexpressed in T cells from patients with systemic lupus erythematosus (SLE). Beyond this, CREMα is also upregulated in a murine model of LPS-induced acute lung injury (ALI).