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YY1 Is a Structural Regulator of Enhancer-Promoter Loops
- Source :
- PMC
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that contribute to structural interactions between gene promoters and their enhancer elements. Large DNA loops that encompass genes and their regulatory elements depend on CTCF-CTCF interactions, but most enhancer-promoter interactions do not employ this structural protein. Here, we show that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF. YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the interaction of these DNA elements. Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression. We propose that YY1-mediated enhancer-promoter interactions are a general feature of mammalian gene control. YY1 is a structural regulator of enhancer-promoter interactions and facilitates gene expression.<br />National Institutes of Health (U.S.) (Grant HG002668/GM123511)<br />National Institutes of Health (U.S.) (Grant R37HD045022/R01-NS088538/R01-MH104610)<br />Virginia and Daniel K. Ludwig Graduate Fellowship<br />National Science Foundation (U.S.). Graduate Research Fellowship Program
- Subjects :
- 0301 basic medicine
Regulation of gene expression
CCCTC-Binding Factor
YY1
Promoter
Biology
General Biochemistry, Genetics and Molecular Biology
Cell biology
Mice
03 medical and health sciences
chemistry.chemical_compound
Enhancer Elements, Genetic
030104 developmental biology
chemistry
CTCF
embryonic structures
Animals
Humans
Promoter Regions, Genetic
Enhancer
Transcription factor
Gene
Embryonic Stem Cells
YY1 Transcription Factor
DNA
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 171
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....a8c6fa467f61a9464496229b16101cf3