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Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ
- Source :
- Experimental and Molecular Pathology. 102:128-132
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Mus pahari is a wild-derived, inbred mouse strain. M. pahari colony managers observed fragility of this strain’s skin resulting in separation of tail skin from the mouse if handled incorrectly. Tail skin tension testing of M. pahari resulted in significantly lowered force threshold for caudal skin rupture and loss in comparison to closely related inbred mouse species and subspecies and even more than a model for junctional epidermolysis bullosa. Histologically, the tail skin separated at the subdermal level with the dermis firmly attached to the epidermis, excluding the epidermolysis bullosa complex of diseases. The dermal collagen bundles were abnormally thickened and branched. Elastin fiber deposition was focally altered in the dermis adjacent to the hair follicle. Collagens present in the skin could not be differentiated between the species in protein gels following digestion with pepsin. Together these data suggest that M. pahari have altered extracellular matrix development resulting in separation of the skin below the level of the dermis with moderate force similar to the African spiny mouse (Acomys spp.).
- Subjects :
- Tail
0301 basic medicine
Clinical Biochemistry
Mice, Inbred Strains
Junctional epidermolysis bullosa (medicine)
Mus pahari
Article
Pathology and Forensic Medicine
03 medical and health sciences
Species Specificity
Dermis
medicine
Animals
Molecular Biology
Skin
integumentary system
biology
Anatomy
medicine.disease
biology.organism_classification
Hair follicle
Molecular biology
Elasticity
Elastin
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
Spiny mouse
biology.protein
Collagen
Epidermolysis bullosa
Epidermis
Subjects
Details
- ISSN :
- 00144800
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Experimental and Molecular Pathology
- Accession number :
- edsair.doi.dedup.....a8baf6f77dc5afba8d37eeb0ef34dbf6