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Indications of a dose-response relationship between cannabis use and age at onset in bipolar disorder
- Source :
- Psychiatry research. 215(1)
- Publication Year :
- 2013
-
Abstract
- Cannabis use seems to play a causal role in the development of psychotic disorders. Recent evidence suggests that it may also precipitate onset in bipolar disorder. We here investigate if there is a dose-response relationship between cannabis use and age at onset in bipolar disorder, and whether there are interactions between cannabis use and illness characteristics (presenting polarity and presence of psychosis). Consecutively recruited patients with a DSM-IV, SCID verified diagnosis of bipolar I, II or NOS disorder (n=324) participated. Two-way ANCOVAS were used to investigate the effect of levels of cannabis use (10 times during one month lifetime,10 times during one month lifetime or a cannabis use disorder) on age at onset, including interaction effects with illness characteristics, while controlling for possible confounders. There was a significant association indicating a dose-response relationship between cannabis use and age at onset, which remained statistically significant after controlling for possible confounders (gender, bipolar subtype, family history of severe mental illness and alcohol or other substance use disorders). There were no interaction effects between cannabis use and presenting polarity or presence of psychosis. Doses of cannabis used may affect the age at onset of bipolar disorder.
- Subjects :
- Adult
Male
Psychosis
medicine.medical_specialty
Bipolar Disorder
Adolescent
Marijuana Smoking
Affect (psychology)
Young Adult
Risk Factors
medicine
Humans
Bipolar disorder
Risk factor
Family history
Age of Onset
Psychiatry
Biological Psychiatry
Aged
biology
Confounding
Middle Aged
medicine.disease
biology.organism_classification
Mental illness
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
Female
Cannabis
Psychology
Clinical psychology
Subjects
Details
- ISSN :
- 18727123
- Volume :
- 215
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Psychiatry research
- Accession number :
- edsair.doi.dedup.....a8a9f2f0e10c3f8b6b090db477fda800