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High-definition transcranial direct-current stimulation of the right M1 further facilitates left M1 excitability during crossed facilitation
High-definition transcranial direct-current stimulation of the right M1 further facilitates left M1 excitability during crossed facilitation
- Source :
- Journal of Neurophysiology. 119:1266-1272
- Publication Year :
- 2018
- Publisher :
- American Physiological Society, 2018.
-
Abstract
- The crossed-facilitation (CF) effect refers to when motor-evoked potentials (MEPs) evoked in the relaxed muscles of one arm are facilitated by contraction of the opposite arm. The aim of this study was to determine whether high-definition transcranial direct-current stimulation (HD-tDCS) applied to the right primary motor cortex (M1) controlling the left contracting arm [50% maximum voluntary isometric contraction (MVIC)] would further facilitate CF toward the relaxed right arm. Seventeen healthy right-handed subjects participated in an anodal and cathodal or sham HD-tDCS session of the right M1 (2 mA for 20 min) separated by at least 48 h. Single-pulse transcranial magnetic stimulation (TMS) was used to elicit MEPs and cortical silent periods (CSPs) from the left M1 at baseline and 10 min into and after right M1 HD-tDCS. At baseline, compared with resting, CF (i.e., right arm resting, left arm 50% MVIC) increased left M1 MEP amplitudes (+97%) and decreased CSPs (−11%). The main novel finding was that right M1 HD-tDCS further increased left M1 excitability (+28.3%) and inhibition (+21%) from baseline levels during CF of the left M1, with no difference between anodal and cathodal HD-tDCS sessions. No modulation of CSP or MEP was observed during sham HD-tDCS sessions. Our findings suggest that CF of the left M1 combined with right M1 anodal or cathodal HD-tDCS further facilitated interhemispheric interactions during CF from the right M1 (contracting left arm) toward the left M1 (relaxed right arm), with effects on both excitatory and inhibitory processing. NEW & NOTEWORTHY This study shows modulation of the nonstimulated left M1 by right M1 HD-tDCS combined with crossed facilitation, which was probably achieved through modulation of interhemispheric interactions.
- Subjects :
- Adult
Male
Physiology
medicine.medical_treatment
Transcranial Direct Current Stimulation
Functional Laterality
050105 experimental psychology
Young Adult
03 medical and health sciences
0302 clinical medicine
Isometric Contraction
medicine
Humans
0501 psychology and cognitive sciences
Muscle, Skeletal
Transcranial direct-current stimulation
business.industry
General Neuroscience
05 social sciences
Motor Cortex
Neural Inhibition
Neurophysiology
Transcranial Magnetic Stimulation
Neuromodulation (medicine)
Arm
Facilitation
High definition
Female
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15221598 and 00223077
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Journal of Neurophysiology
- Accession number :
- edsair.doi.dedup.....a89d3fd55df8a0dc1f1f26aa603fe918
- Full Text :
- https://doi.org/10.1152/jn.00861.2017