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Endogenous n-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8+ T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice
- Source :
- International Journal of Molecular Sciences, Volume 20, Issue 18, International Journal of Molecular Sciences, Vol 20, Iss 18, p 4510 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been known to exert anti-inflammatory effects on various disease states. However, its effect on CD8+ T cell-mediated immunopathology upon viral infection has not been well elucidated yet. In this study, we investigated the possible implication of n-3 PUFAs in CD8+ T cell responses against an acute viral infection. Infection of FAT-1 transgenic mice that are capable of synthesizing n-3 PUFAs from n-6 PUFAs with lymphocytic choriomeningitis virus (LCMV) resulted in significant reduction of anti-viral CD8+ T cell responses. Interestingly, expansion of adoptively transferred wild-type (WT) LCMV-specific T cell receptor (TCR) transgenic CD8+ (P14) T cells into FAT-1 mice was significantly decreased. Also, activation of anti-viral CD4+ helper T cells was reduced in FAT-1 mice. Importantly, P14 cells carrying the fat-1 gene that were adoptively transferred into WT mice exhibited a substantially decreased ability to proliferate and produce cytokines against LCMV infection. Together, n-3 PUFAs attenuated anti-viral CD8+ T cell responses against an acute viral infection and thus could be used to alleviate immunopathology mediated by the viral infection.
- Subjects :
- viruses
T cell
Transgene
CD8+ T cell
Mice, Transgenic
Endogeny
CD8-Positive T-Lymphocytes
Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis
Article
Catalysis
lcsh:Chemistry
Inorganic Chemistry
Mice
Fatty Acids, Omega-3
medicine
Animals
Lymphocytic choriomeningitis virus
immunopathology
Cytotoxic T cell
Physical and Theoretical Chemistry
LCMV
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Inflammation
chemistry.chemical_classification
Chemistry
Organic Chemistry
T-cell receptor
General Medicine
medicine.disease
Computer Science Applications
Mice, Inbred C57BL
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
Immunology
omega-3
CD8
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....a879e3d0fe9be4a58069ff5e651552e9
- Full Text :
- https://doi.org/10.3390/ijms20184510