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Radiotherapy is not associated with an increased rate of Second Primary Tumours in Oral Squamous Carcinoma: A study of 370 patients
- Source :
- Oral Oncology. 45:941-945
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Oral Squamous Cell Carcinoma (OSCC) remains a public health scourge. Radiotherapy (RT) is a major treatment modality and has been implicated in possible formation of Second Primary Tumours (SPT). In a single centre retrospective study of 370 patients with OSCCs (1967-2004) associations between RT, diagnosis of SPTs, median SPT diagnostic time lag, Disease Free Survival (DFS) and overall survival (OS) were analysed. Sixty-eight (18.4%) patients developed metachronous SPTs. Two hundred and twenty patients (59.3%) underwent some form of RT whilst 151 (40.7%) patients were not exposed to RT. No significant increased incidence of SPTs was demonstrated in the RT group. No significant difference in SPT diagnostic time lag was noted amongst the groups. This study suggests that RT is neither a risk for SPT induction nor increases the relative diagnostic time delay of upper aero-digestive tract SPTs.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Neoplasms, Radiation-Induced
medicine.medical_treatment
Disease-Free Survival
Risk Factors
Internal medicine
medicine
Carcinoma
Humans
Aged
Retrospective Studies
Mouth neoplasm
business.industry
Incidence (epidemiology)
Cancer
Neoplasms, Second Primary
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Surgery
Squamous carcinoma
Radiation therapy
stomatognathic diseases
Epidermoid carcinoma
Carcinoma, Squamous Cell
Radiation Oncology
Female
Mouth Neoplasms
New South Wales
Oral Surgery
business
Subjects
Details
- ISSN :
- 13688375 and 19672004
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Oral Oncology
- Accession number :
- edsair.doi.dedup.....a8793d6eb351404da33b3e4d19092141