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The effect of negative pressure wound therapy with antibacterial dressings or antiseptics on an in vitro wound model
- Source :
- Journal of Wound Care. 26:236-242
- Publication Year :
- 2017
- Publisher :
- Mark Allen Group, 2017.
-
Abstract
- Objective: The aim of this study was to investigate the bacterial bioburden in experimental in vitro wounds during the application of conventional negative pressure wound therapy (NPWT), with and without antimicrobial dressings (polyhexanide, silver), against NPWT instillation of octenidine. Method: Experimental wounds produced in an in vitro porcine wound model were homogenously contaminated with bacterial suspension and treated with NPWT and different options. Group A: non-antimicrobial polyurethane foam dressing; group B: antimicrobial polyurethane foam dressing containing silver; group C: antimicrobial gauze dressing containing polyhexanide; group D: non-antimicrobial polyurethane foam dressing intermittently irrigated with octenidine; group E: negative control (non-antimicrobial polyurethane foam dressing without NPWT). Standard biopsies were harvested after 24 and 28 hours. Results: This study demonstrated that the use of NPWT with intermitted instillation of octenidine (group D) or application of silver-based polyurethane foam dressings (group B) is significantly superior against Staphylococcus aureus colonisation in experimental wounds compared with non-antimicrobial polyurethane foam dressing (group A) after 48 hours. Surprisingly, the polyhexanide-based dressing (group C) used in this model showed no statistical significant effect compared with the control group (group E) after 24 or 48 hours of treatment. Conclusion: Both intermitted instillation of octenidine and silver-based dressings in standard NPWT were significantly superior compared with non-antimicrobial polyurethane foam dressings or PHMB coated gauze dressing after 48 hours.
- Subjects :
- Staphylococcus aureus
medicine.medical_specialty
Silver
Nursing (miscellaneous)
Pyridines
Swine
medicine.medical_treatment
Polyurethanes
Polyhexanide
Negative control
In Vitro Techniques
Bioburden
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Negative-pressure wound therapy
Animals
Medicine
030212 general & internal medicine
integumentary system
business.industry
Staphylococcal Infections
Antimicrobial
Bandages
Wound infection
Surgery
chemistry
Anti-Infective Agents, Local
Wound Infection
Wounds and Injuries
Fundamentals and skills
Imines
business
Negative-Pressure Wound Therapy
Subjects
Details
- ISSN :
- 20522916 and 09690700
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Wound Care
- Accession number :
- edsair.doi.dedup.....a86e50fc3f6c7d1263feccfe326adb16