Additional file 1 of Development of fluorescence/MR dual-modal manganese-nitrogen-doped carbon nanosheets as an efficient contrast agent for targeted ovarian carcinoma imaging

Additional file 1: Figure S1. Optimization of reaction conditions. Figure S2. Typical EDS pattern of Mn-N-CNSs. Figure S3. Stability of the Mn-N-CNSs in different biological fluids. Figure S4. The fluorescence stability of Mn-N-CNSs. Figure S5. Effect of pH (A) and ionic strengths (B) on the fluorescence intensity of Mn-N-CNSs. Figure S6. Fluorescence (A) and T1-weighted images as well as T1 relaxation time (B) of urine samples, taken ~ 12 h after the injection of Mn-N-CNSs@Anti-HE4. Figure S7. Complete blood count study of the mice treated by Mn-N-CNSs@Anti-HE4 at various concentraions for 1, 8, 22 days. Figure S8. Body weight changes of the mice after the administration of Mn-N-CNSs and saline for different days.