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Establishing a New Animal Model for the Study of Laryngeal Biology and Disease: An Anatomic Study of the Mouse Larynx
- Source :
- Journal of Speech, Language, and Hearing Research. 52:802-811
- Publication Year :
- 2009
- Publisher :
- American Speech Language Hearing Association, 2009.
-
Abstract
- Purpose Animal models have contributed greatly to the study of voice, permitting the examination of laryngeal biology and the testing of surgical, medical, and behavioral interventions. Various models have been used. However, until recently, the mouse (Mus musculus ) has not been used in laryngeal research, and features of the mouse larynx have not been defined. Therefore, the purpose of this study was to qualitatively describe mouse laryngeal anatomy in relation to known human anatomy. Methods Larynges of 7 C57BL mice were examined and photographed under stereotactic and light microscopy. Results The authors found that mouse laryngeal organization was similar to that of humans. The hyoid bone and epiglottal, thyroid, cricoid, and arytenoid cartilages were identified. An additional cartilage was present ventrally. Thyroarytenoid, posterior cricoarytenoid, lateral cricoarytenoid, and cricothyroid muscles were grossly positioned as in humans. Interarytenoid muscles were not present; however, a functional counterpart was identified. Conclusions The authors provide an initial description of mouse laryngeal anatomy. Because of its amenability to genetic engineering, the mouse is the premiere model for the study of disease and the testing of interventions. Introduction of the mouse model for laryngeal study offers a tool for the study of normal laryngeal cell biology and tissue response to disease processes.
- Subjects :
- Male
Models, Anatomic
Larynx
Linguistics and Language
Pathology
medicine.medical_specialty
MEDLINE
Disease
Biology
Bioinformatics
Language and Linguistics
Cricoid Cartilage
Laryngeal Diseases
Mice
Speech and Hearing
Animal model
Neck Muscles
medicine
Animals
Behavioral interventions
Hyoid Bone
Organ Size
Mice, Inbred C57BL
Disease Models, Animal
medicine.anatomical_structure
Mouse Larynx
Thyroid Cartilage
Models, Animal
Neck
Arytenoid Cartilage
Subjects
Details
- ISSN :
- 15589102 and 10924388
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Journal of Speech, Language, and Hearing Research
- Accession number :
- edsair.doi.dedup.....a85f68ba327fd1f5e87fde9fddfcc462