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Impact of Sedation on Cognitive Function in Mechanically Ventilated Patients
- Source :
- Lung. 194(1)
- Publication Year :
- 2015
-
Abstract
- The practice of sedation dosing strategy in mechanically ventilated patient has a profound effect on cognitive function. We conducted a comprehensive review of outcome of sedation on mental health function in critically ill patients on mechanical ventilation in the intensive care unit (ICU). We specifically evaluated current sedative dosing strategy and the development of delirium, post-traumatic stress disorders (PTSDs) and agitation. Based on this review, heavy dosing sedation strategy with benzodiazepines contributes to cognitive dysfunction. However, outcome for mental health dysfunction is mixed in regard to newer sedatives agents such as dexmedetomidine and propofol. Moreover, studies that examine the impact of sedatives for persistence of PTSD/delirium and its long-term cognitive and functional outcomes for post-ICU patients are frequently underpowered. Most studies suffer from low sample sizes and methodological variations. Therefore, larger randomized controlled trials are needed to properly assess the impact of sedation dosing strategy on cognitive function.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Critical Care
medicine.drug_class
Sedation
law.invention
Stress Disorders, Post-Traumatic
03 medical and health sciences
Benzodiazepines
0302 clinical medicine
Cognition
Randomized controlled trial
law
Risk Factors
medicine
Humans
Hypnotics and Sedatives
030212 general & internal medicine
Dosing
Dexmedetomidine
Intensive care medicine
business.industry
Delirium
030208 emergency & critical care medicine
Intensive care unit
Respiration, Artificial
Sedative
medicine.symptom
business
Propofol
Cognition Disorders
medicine.drug
Akathisia, Drug-Induced
Subjects
Details
- ISSN :
- 14321750
- Volume :
- 194
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Lung
- Accession number :
- edsair.doi.dedup.....a84d2d62b0238345b13b5df409959906