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ω3 polyunsaturated fatty acids as immunomodulators in colorectal cancer: new potential role in adjuvant therapies
- Source :
- Frontiers in Immunology, Vol 7 (2016), Frontiers in Immunology
- Publication Year :
- 2016
- Publisher :
- Frontiers Media S.A., 2016.
-
Abstract
- Diet composition may affect the onset and progression of chronic degenerative diseases, including cancer, whose pathogenesis relies on inflammatory processes. Growing evidence indicates that diet and its components critically contribute to human health, affecting the immune system, secretion of adipokines, and metabolic pathways. Colorectal cancer (CRC) is one of the leading causes of death worldwide. Antineoplastic drugs are widely used for CRC treatment, but drug resistance and/or off-target toxicity limit their efficacy. Dietary ω3 polyunsaturated fatty acids (PUFA) have been gaining great interest in recent years as possible anti-inflammatory and anticancer agents, especially in areas such as the large bowel, where the pro-inflammatory context promotes virtually all steps of colon carcinogenesis. Growing epidemiological, experimental, and clinical evidence suggests that ω3 PUFA may play a role in several stages of CRC management exhibiting antineoplastic activity against human CRC cells, improving the efficacy of radiation and chemotherapy, ameliorating cancer-associated secondary complications, and preventing CRC recurrence. These effects are most likely related to the immunomodulatory activities of ω3 PUFA that are able to influence several aspects of the inflammatory process ranging from inflammasome activation, leukocyte recruitment, production of immune mediators to differentiation, and activation of immune cells. In this review, we will focus on the potential use of ω3 PUFA as adjuvant agents together with chemo/radiotherapy, highlighting the immunomodulatory effects most likely responsible for their beneficial effects in different stages of CRC management.
- Subjects :
- 0301 basic medicine
lcsh:Immunologic diseases. Allergy
Colorectal cancer
medicine.medical_treatment
Mini Review
Immunology
Context (language use)
colorectal cancer
Bioinformatics
Immunomodulation
03 medical and health sciences
0302 clinical medicine
Immune system
medicine
Adjuvant therapy
Immunology and Allergy
chemistry.chemical_classification
Inflammation
business.industry
Cancer
Inflammasome
adjuvant therapy
medicine.disease
ω3 polyunsaturated fatty acids
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
business
lcsh:RC581-607
Adjuvant
medicine.drug
Polyunsaturated fatty acid
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....a82f4017264a43b86b0e60a384cb793d