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Outcome of liver disease in a large cohort of histologically proven chronic hepatitis C: influence of HCV genotype
- Source :
- European journal of gastroenterologyhepatology. 13(5)
- Publication Year :
- 2001
-
Abstract
- Objective To assess the influence of hepatitis C virus (HCV) genotypes on the clinical outcome of liver disease, we analysed 2307 patients. Results The most frequently represented genotypes were 1 b (40%) and 2 (28.1%). Patients with these genotypes had a median age higher than patients with other genotypes (P < 0.01). The overall survival of subjects with genotype 1 b was poorer than the survival of patients with other genotypes (P< 0.01). Liver cirrhosis was found in 280 patients (12.1%), and type 1 b was the most represented isolate among them (P < 0.01). Sixty-two patients (22%) developed hepatocellular carcinoma (HCC) during a follow-up of 1481.8 cumulative years (estimated crude incidence rate, 4.1 cases per 100 person-years for all cirrhotics; 5.9 cases for genotype 1 a; 4.5 cases for genotype 1 b; and 2.8 cases for genotypes non-1). Considering the whole population of 2307 patients, only genotype 1 b was associated significantly with both cirrhosis and the development of HCC. One hundred and nineteen cirrhotic patients underwent treatment with interferon in uncontrolled studies. Interferon therapy was associated with both better survival (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Cirrhosis
Adolescent
Genotype
Hepatitis C virus
Biopsy
Population
Hepacivirus
medicine.disease_cause
Gastroenterology
Antiviral Agents
Cohort Studies
Liver disease
Predictive Value of Tests
Risk Factors
Internal medicine
Medicine
Humans
education
Survival analysis
Aged
Retrospective Studies
education.field_of_study
Hepatology
business.industry
Hepatitis C
Hepatitis C, Chronic
Middle Aged
medicine.disease
Prognosis
Survival Analysis
Treatment Outcome
Liver
Hepatocellular carcinoma
Immunology
Female
Interferons
business
Subjects
Details
- ISSN :
- 0954691X
- Volume :
- 13
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of gastroenterologyhepatology
- Accession number :
- edsair.doi.dedup.....a820e077ca5f086c07720c4e44722ee0