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Pilosebaceous Malignant Transformation of Dermoid Cyst in the Orbit
- Source :
- Ophthalmic plastic and reconstructive surgery. 36(4)
- Publication Year :
- 2020
-
Abstract
- Dermoid cysts may occur in the orbit, most commonly in the superolateral area. Malignant transformation of such lesions has been previously reported; however, most turn out to be squamous cell carcinoma. The authors' patient initially presented with mild proptosis and limitation in extraocular movements. Preliminary biopsy showed whitish amorphous material and abundant hairs filling the thin-walled cyst, consistent with dermoid cyst. The patient underwent tumor resection via lateral orbitotomy with bone window and transorbital endoscopic approach for the dural involvement. Final biopsy showed dermoid cyst with pilosebaceous malignant transformation showing p53 expression and 30% of Ki-67 index. Adjuvant radiotherapy was performed. To the best of the authors' knowledge, this is the first reported case of this type. Despite its rarity, there should always be a high index of suspicion and complete work-up for an accurate diagnosis.
- Subjects :
- Adult
Male
medicine.medical_specialty
business.operation
Biopsy
Tumor resection
Malignant transformation
03 medical and health sciences
0302 clinical medicine
otorhinolaryngologic diseases
medicine
Humans
Cyst
P53 expression
Dermoid Cyst
medicine.diagnostic_test
business.industry
General Medicine
medicine.disease
Ophthalmology
medicine.anatomical_structure
Cell Transformation, Neoplastic
Dermoid cyst
030221 ophthalmology & optometry
Carcinoma, Squamous Cell
Surgery
Radiology
business
Transorbital
Orbit
Orbit (anatomy)
Subjects
Details
- ISSN :
- 15372677
- Volume :
- 36
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Ophthalmic plastic and reconstructive surgery
- Accession number :
- edsair.doi.dedup.....a81df160155c1c1cb34a5a9064cedb39