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Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice
- Source :
- Mucosal Immunology. 5:87-98
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Neonatal Fc receptors for immunoglobulin (Ig)G (FcRn) assume a central role in regulating host IgG levels and IgG transport across polarized epithelial barriers. We have attempted to elucidate the contribution of FcRn in controlling Helicobacter infection in the stomach. C57BL/6J wild-type or FcRn(-/-) mice were infected with Helicobacter heilmannii, and gastric lesions, bacterial load and the levels of antigen-specific IgG in serum and gastric juice were analyzed. The elevated levels of anti-H. heimannii IgG in gastric juice were observed exclusively in wild-type mice but not in FcRn(-/-) mice. In contrast, an increase in lymphoid follicles and bacterial loads along with deeper gastric epithelium invasion were noted in FcRn(-/-) mice. C57BL/6J wild-type or FcRn(-/-) mice were also infected with Helicobacter pylori SS1, and the results of the bacterial load in stomachs of these mice and the anti-H. pylori IgG levels in serum and gastric juice were similar to those from H. heilmannii infection. Our data suggest that FcRn can be functionally expressed in the stomach, which is involved in transcytosis of IgG, and prevent colonization by H. heilmannii and the associated pathological consequences of infection.
- Subjects :
- Helicobacter heilmannii
Immunology
Receptors, Fc
Article
Immunoglobulin G
Helicobacter Infections
Microbiology
Mice
Neonatal Fc receptor
Intestinal mucosa
medicine
Animals
Immunology and Allergy
Helicobacter
Intestinal Mucosa
Mice, Knockout
Helicobacter pylori
Virulence
biology
Stomach
Histocompatibility Antigens Class I
biology.organism_classification
Antibodies, Bacterial
Mice, Inbred C57BL
medicine.anatomical_structure
biology.protein
Antibody
Transcytosis
Subjects
Details
- ISSN :
- 19330219
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Mucosal Immunology
- Accession number :
- edsair.doi.dedup.....a81d19663b9fd1713a8790230a97d050