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Lung cancer in combined pulmonary fibrosis and emphysema: a series of 47 Western patients
- Source :
- Journal of Thoracic Oncology, Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2014, 9 (8), pp.1162--1170. ⟨10.1097/JTO.0000000000000209⟩, Journal of Thoracic Oncology, 2014, 9 (8), pp.1162--1170. ⟨10.1097/JTO.0000000000000209⟩
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- International audience; INTRODUCTION: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterized by imaging features consisting of the association of centrilobular and/or paraseptal emphysema and pulmonary fibrosis. Virtually all patients are smokers and thus at high risk of developing lung cancer. METHODS: This retrospective multicentre study was conducted by the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). RESULTS: A total of 47 patients presenting with lung cancer and CPFE syndrome were identified. All patients were smokers, with a mean of 47 pack-years. A pathological diagnosis of lung cancer was obtained for 38 (81%) patients. Histological type was squamous cell carcinoma in 17 (36%) patients, adenocarcinoma in 14 (30%), non-small-cell lung cancer not otherwise specified in three (6%), small-cell lung cancer in three (6%), and sarcomatoid carcinoma in one (2%). Overall, 20 of the 47 patients could not receive standard-of-care treatment for lung cancer, as per international recommendations or guidelines; this limitation was considered to be directly related to the CPFE syndrome in eight (40%) cases. CONCLUSION: Lung cancer in patients with CPFE syndrome represents a specific entity with a poor prognosis, that further represents the most characteristic and severe model of tobacco-related disease.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Lung Neoplasms
Antineoplastic Agents, Hormonal
Pulmonary Fibrosis
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Vital Capacity
Gastroenterology
03 medical and health sciences
Pneumonectomy
0302 clinical medicine
Forced Expiratory Volume
Internal medicine
Pulmonary fibrosis
medicine
Humans
Lung cancer
Sarcomatoid carcinoma
Survival rate
Aged
Retrospective Studies
Emphysema
Pulmonary Gas Exchange
business.industry
Smoking
Not Otherwise Specified
Syndrome
Middle Aged
respiratory system
medicine.disease
Combined pulmonary fibrosis and emphysema
3. Good health
respiratory tract diseases
Survival Rate
Dyspnea
030228 respiratory system
Oncology
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Radiotherapy, Adjuvant
France
Tomography, X-Ray Computed
business
Subjects
Details
- Language :
- English
- ISSN :
- 15560864 and 15561380
- Database :
- OpenAIRE
- Journal :
- Journal of Thoracic Oncology, Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2014, 9 (8), pp.1162--1170. ⟨10.1097/JTO.0000000000000209⟩, Journal of Thoracic Oncology, 2014, 9 (8), pp.1162--1170. ⟨10.1097/JTO.0000000000000209⟩
- Accession number :
- edsair.doi.dedup.....a815374850ddd2dcc3b6a2c413f47a7b