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Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide Population-Based Study
- Source :
- Diabetes Care, Choi, Y-J, Han, K-D, Choi, E-K, Jung, J-H, Lee, S-R, Oh, S & Lip, G Y H 2021, ' Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus : A Nationwide Population-Based Study ', Diabetes Care, vol. 44, no. 6, pp. 1393-1401 . https://doi.org/10.2337/dc20-2607
- Publication Year :
- 2021
- Publisher :
- American Diabetes Association, 2021.
-
Abstract
- OBJECTIVE To investigate the effects of alcohol abstinence on prevention of new-onset atrial fibrillation (AF) in patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS A total of 1,112,682 patients newly diagnosed with T2DM between 2011 and 2014 were identified from the Korean National Health Insurance Service database. After excluding those with a history of AF, 175,100 patients were included. The primary outcome was new-onset AF. RESULTS During a mean follow-up of 4.0 years, AF occurred in 4,174 patients. Those with heavy alcohol consumption (alcohol intake ≥40 g/day) before T2DM diagnosis had a higher risk of AF (adjusted hazard ratio [aHR] 1.22; 95% CI 1.06–1.41) compared with patients with no alcohol consumption. After T2DM diagnosis, those with moderate to heavy alcohol consumption (alcohol intake ≥20 g/day) who abstained from alcohol had a lower risk of AF (aHR 0.81; 95% CI 0.68–0.97) compared with constant drinkers. Alcohol abstinence showed consistent trends toward lower incident AF in all subgroups and was statistically significant in men (aHR 0.80; 95% CI 0.67–0.96), those aged >65 years (aHR 0.69; 95% CI 0.52–0.91), those with CHA2DS2-VASc score CONCLUSIONS In patients with newly diagnosed T2DM, alcohol abstinence was associated with a low risk of AF development. Lifestyle modifications, such as alcohol abstinence, in patients newly diagnosed with T2DM should be recommended to reduce the risk of AF.
- Subjects :
- Male
Research design
Cardiovascular and Metabolic Risk
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Alcohol
Lower risk
Risk Assessment
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Diabetes mellitus
Internal medicine
Atrial Fibrillation
Internal Medicine
medicine
Humans
030212 general & internal medicine
Advanced and Specialized Nursing
Alcohol Abstinence
business.industry
Hazard ratio
Type 2 Diabetes Mellitus
Atrial fibrillation
medicine.disease
Stroke
Diabetes Mellitus, Type 2
chemistry
business
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....a81477ec3821d767352f9c26939130de