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Revisiting maintenance therapy in acute myeloid leukemia with novel agents
- Source :
- Current opinion in hematology. 23(2)
- Publication Year :
- 2016
-
Abstract
- Purpose of review High relapse rates and therapy-related toxicity contribute to suboptimal outcomes in acute myeloid leukemia (AML) patients attaining a remission following initial induction therapy and postallogeneic stem cell transplant. Maintenance therapy holds the potential for a prolonged remission interval analogue to that seen in other hematologic malignancies. Herein we present and analyze the current data in the field. Recent findings Maintenance treatment approaches utilizing conventional chemotherapy, immunomodulation, hypomethylating agents, targeted small molecules, and tyrosine kinase inhibitors have been explored in this setting. The published data have not yet demonstrated convincing efficacy to merit establishment of this approach as standard of care. The role of hypomethylating agents and novel tyrosine kinase inhibitors is being actively studied in phase II/III trials and may improve patient outcome. Summary Maintenance therapy has not been shown to improve patient outcome in AML. The results of ongoing and future studies with novel agents may facilitate incorporation of this approach to standard care of AML.
- Subjects :
- Oncology
medicine.medical_specialty
Myeloid
medicine.medical_treatment
Hematopoietic stem cell transplantation
Maintenance Chemotherapy
03 medical and health sciences
0302 clinical medicine
Maintenance therapy
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Combined Modality Therapy
Humans
Transplantation, Homologous
Molecular Targeted Therapy
business.industry
Remission Induction
Hematopoietic Stem Cell Transplantation
Myeloid leukemia
Hematology
medicine.disease
Transplantation
Leukemia
Leukemia, Myeloid, Acute
medicine.anatomical_structure
Treatment Outcome
030220 oncology & carcinogenesis
Immunology
Retreatment
Stem cell
business
030215 immunology
Subjects
Details
- ISSN :
- 15317048
- Volume :
- 23
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Current opinion in hematology
- Accession number :
- edsair.doi.dedup.....a81127bd21716071db915aa7d76c8812