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Is Serum Cystatin C a Sensitive Marker of Glomerular Filtration Rate (GFR)? A Preliminary Study on Renal Transplant Patients
- Source :
- Renal Failure. 20:303-309
- Publication Year :
- 1998
- Publisher :
- Informa UK Limited, 1998.
-
Abstract
- Human cystatin C is a basic low molecular mass protein (13,359 Dalton) freely filtered through the glomerulus and almost completely re-absorbed and catabolized by proximal tubular cells. We measured serum cystatin C in 38 kidney transplant patients (23 males, 15 females) aged between 6 and 32 years. To assess renal function, serum and urinary creatinine were also determined in all patients, and creatinine clearance was finally calculated. Cystatin C was determined by a particle-enhanced turbidimetric assay, and creatinine was measured by gas chromatography-mass spectrometry. To compare the diagnostic efficiency of cystatin C with that of creatinine, inulin clearance was performed on 12 renal transplant patients, and receiver operating characteristic (ROC) analysis was applied. The results of this study demonstrate that serum cystatin C significantly increases in renal transplant patients with reduced creatinine clearance (70 mL/min per 1.73 m2) and that the diagnostic accuracy of serum cystatin C is better than of serum creatinine. Cystatin C may be utilized as a very marker of reduced GFR.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Urinary system
Urology
Renal function
Cysteine Proteinase Inhibitors
Glomerulus (kidney)
Kidney
urologic and male genital diseases
Critical Care and Intensive Care Medicine
Gas Chromatography-Mass Spectrometry
Body Mass Index
chemistry.chemical_compound
Nephelometry and Turbidimetry
Predictive Value of Tests
Serum cystatin
Internal medicine
medicine
Humans
Cystatin C
Child
reproductive and urinary physiology
Creatinine
Inulin Clearance
biology
Receiver operating characteristic
business.industry
Inulin
General Medicine
Cystatins
Kidney Transplantation
female genital diseases and pregnancy complications
medicine.anatomical_structure
Endocrinology
ROC Curve
chemistry
Nephrology
biology.protein
Female
business
Biomarkers
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 15256049 and 0886022X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Renal Failure
- Accession number :
- edsair.doi.dedup.....a80fef4f28bec5a2c30af8c2791ad76a