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Serum Cytokine Profiling in Cats with Acute Idiopathic Cystitis
- Source :
- Journal of Veterinary Internal Medicine, Parys, M, Yuzbasiyan Gurkan, V & Kruger, J 2018, ' Serum Cytokine Profiling in Cats with Acute Idiopathic Cystitis ', Journal of Veterinary Internal Medicine, vol. 32, no. 1, pp. 274-279 . https://doi.org/10.1111/jvim.15032
- Publication Year :
- 2017
-
Abstract
- Background: Feline idiopathic cystitis (FIC) is a common lower urinary tract disorder of domestic cats that resembles interstitial cystitis/painful bladder syndrome (IC/PBS) in humans. Diagnosis of FIC is based on clinical signs and exclusion of other disorders because of a lack of specific pathologic findings or other objective biomarkers. Cytokines are potential noninvasive biomarkers to define the presence, severity, and progression of disease, and response to treatment. Objectives: The objective of this pilot study was to determine concentrations of selected cytokines in serum from healthy cats and cats with acute FIC. Animals: Serum samples from 13 healthy cats and from 12 cats with nonobstructive acute FIC were utilized. Methods: Multiplex analysis of 19 cytokines (CCL2, CCL5, CXCL1, CXCL12, CXCL8, Flt3L, GM-CSF, IFN-c, IL-12 (p40), IL-13, IL-18, IL-1b, IL-2, IL-4, IL-6, PDGF-BB, SCF, sFas, and TNF-a) was performed with a commercially available feline-specific multiplex bead-based assay. Results: Mean serum concentrations of IL-12 (p40; P < 0.0001), CXCL12 (P = 0.002), IL-18 (P = 0.032), and Flt3L (P = 0.0024) were significantly increased in FIC cats compared to healthy cats. GM-CSF, IL-1b, IL-2, and PDGF-BB were undetectable or detected in an insufficient number of cats to allow meaningful comparisons. Conclusions and Clinical Importance: We have identified increased serum concentrations of pro-inflammatory cytokines and chemokines CXCL12, IL-12, IL-18, and Flt3L in FIC-affected cats. These findings suggest potential candidates for noninvasive biomarkers for diagnosis, staging, and therapeutic outcome monitoring of affected cats and provide additional insight into the etiopathogenesis of FIC. Key words: Feline; Interstitial; Multiplex assay; Urine.
- Subjects :
- 0301 basic medicine
Male
Chemokine
Pilot Projects
Disease
Urine
Cat Diseases
Gastroenterology
0403 veterinary science
Cystitis
Nephrology/Urology
CATS
biology
Interleukin-18
Interstitial cystitis
04 agricultural and veterinary sciences
Interleukin-12
Standard Articles
CXCL1
Multiplex assay
Chemokines, CC
Acute Disease
Cytokines
Female
medicine.medical_specialty
040301 veterinary sciences
Brief Communication
CCL5
Feline
03 medical and health sciences
Interferon-gamma
Internal medicine
medicine
Animals
Retrospective Studies
General Veterinary
business.industry
Tumor Necrosis Factor-alpha
Interleukins
medicine.disease
Urinary tract disorder
Chemokine CXCL12
030104 developmental biology
Case-Control Studies
biology.protein
Cats
SMALL ANIMAL
business
Interstitial
Biomarkers
Subjects
Details
- ISSN :
- 19391676
- Volume :
- 32
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of veterinary internal medicine
- Accession number :
- edsair.doi.dedup.....a805c96a9f03c16563dbcb627fb3dbb3