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Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation
- Source :
- International journal of radiation biology. 94(2)
- Publication Year :
- 2017
-
Abstract
- There remains an unmet medical need for radioprotective and mitigative agents. BP-C2 is a novel lignin-derived polyphenolic composition with ammonium molybdate, developed as radioprotector/radiomitigator.The present study evaluated BP-C2 for the mitigation of acute radiation syndrome (ARS).A total-body irradiation mouse model (TBI, 4.0-8.0 Gy) was used in the study.In a 30-day survival study, performed in CBA mice, BP-C2, at a dosage of 81.0 mg/kg, improved survival (dose reduction factor (DRF) = 1.1) and increased the formation of endogenous spleen colony-forming units (CFU). In C57BL/6 mice, BP-C2, when administered daily for 7 days, starting 24 hours after TBI, also improved survival. In animals irradiated with 5.0 Gy, BP-C2 increased the number of CFUs (6.7 ± 5.1) compared to the 5.0 Gy placebo group (2.3 ± 2.3, p = .0245). The number of surviving intestinal crypts was maintained in the 5.0 Gy BP-C2 group (133.7 ± 13.9), in contrast to the 5.0 Gy placebo group (124.2 ± 10.5, p .0023). BP-C2 also increased the number of LGR5 + positive cells in intestinal crypts.BP-C2 mitigates radiation-induced damage in mid-lethal range of radiation doses. Effects are mediated by enhancement of extramedullar hematopoiesis in the spleen and a protective effect on the intestinal epithelium.
- Subjects :
- 0301 basic medicine
Male
Cell Survival
Spleen
Endogeny
Radiation-Protective Agents
Pharmacology
Placebo
Lignin
03 medical and health sciences
Mice
0302 clinical medicine
medicine
Animals
Radiology, Nuclear Medicine and imaging
Cell Proliferation
Ammonium molybdate
Molybdenum
Radiological and Ultrasound Technology
Chemistry
Stem Cells
Acute Radiation Syndrome
Polyphenols
Total body irradiation
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Polyphenol
030220 oncology & carcinogenesis
Leukocytes, Mononuclear
Mice, Inbred CBA
Composition (visual arts)
Whole-Body Irradiation
Subjects
Details
- ISSN :
- 13623095
- Volume :
- 94
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International journal of radiation biology
- Accession number :
- edsair.doi.dedup.....a8056c8384bb6ac8ae4fd9360960e85f